Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds

doi:10.1021/acscatal.7b00078

	Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds
	Wu, Yunxiang 1,2; Zhou, Bing1,2
刊名	ACS CATALYSIS
	2017-03
卷号	7 期号:3 页码:2213-2217
关键词	C-H activation ruthenium hydroxymethylation hydroxymethylarene formaldehyde
ISSN号	2155-5435
DOI	10.1021/acscatal.7b00078
文献子类	Article
英文摘要	An ideal addition of "inert" aryl C-H bonds to formaldehyde has been achieved to synthesize a variety of hydroxymethylarenes via a Ru(II)-catalyzed C-H activation. Many different directing groups (not limited to strongly heterocyclic directing groups) can be used, and this challenging C-H hydroxymethylation proceeds in the presence of water and air, without stoichiometric undesirable byproducts, thus offering an environmentally benign method of hydroxymethylarene synthesis that can be readily scaled up.
资助项目	CAS Pioneer Hundred Talents Program[00000000] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020333]
WOS关键词	OXIDATIVE ORTHO-ACYLATION ; O-METHYL OXIMES ; HETEROAROMATIC BASES ; CONVERGENT SYNTHESIS ; ORTHO-ALKENYLATION ; RHODIUM CATALYSIS ; CYCLATIVE CAPTURE ; ROOM-TEMPERATURE ; ACTIVATION ; ALDEHYDES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000395726500085
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272764]
专题	药物化学研究室
通讯作者	Zhou, Bing
作者单位	1.Chinese Acad Sci, SIMM, Dept Med Chem, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yunxiang,Zhou, Bing. Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds[J]. ACS CATALYSIS,2017,7(3):2213-2217.
APA	Wu, Yunxiang,&Zhou, Bing.(2017).Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds.ACS CATALYSIS,7(3),2213-2217.
MLA	Wu, Yunxiang,et al."Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds".ACS CATALYSIS 7.3(2017):2213-2217.