Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats

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	Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats
	Guo Xiangyu 2; Duan Ying 1; Li Juane 2; Sun Wen 2; Wang Zhicheng 2; Wang Heyao3 ; Liu Tonghua 2
刊名	China Journal of Traditional Chinese Medicine and Pharmacy
	2010
卷号	25 期号:12 页码:2291-2294
关键词	Saururus Chinensis Antidiabetic effects Obese Zucker rats Insulin resistance Glucose clamp technique
ISSN号	1673-1727
其他题名	三白草提取物对肥胖Zucker大鼠胰岛素抵抗的疗效观察
文献子类	Article
英文摘要	Objective:To observe the effects of Saururus Chinensis on glucose metabolism and insulin resistance in obese Zucker rats. Methods:12 male obese Zucker rats,6 weeks old, were randomly divided into control group and Saururus Chinensis group(350mg/kg)after being fed for 2 weeks. All rats were feed with high fat diet and 4-week treatment. Body weight, food intake, and random blood glucose were tested every week. OGTT and fasting insulin level were tested on day 0, day 14 and day 28.TG,TC,HDL,LDL and FFA were tested on day 28. Glucose infusion rates were tested by hyperinsulinemic-euglycemic clamp from day 29. Results:Compared with the control group, the fed blood glucose had a significant decline in Saururus Chinensis-treated rats on day 28, even though there was no alteration of the fasting serum insulin and OGTT.The glucose infusion rates increased slightly in hyperinsulinemic-euglycemic clamp study. Furthermore, Body weight and FFA were decreased in Saururus Chinensis group. However, Saururus Chinensis had no significant effect on lipids in obese Zucker rats. Conclusion: Saururus Chinensis may improve glucose metabolism by reducing insulin resistance
资助项目	北京市教育委员会共建项目[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4108435
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267915]
专题	药理学第三研究室
作者单位	1.Beijing Tongren Hospital, Beijing 100730, China.; 2.Beijing University of TCM, Beijing 100029, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Guo Xiangyu,Duan Ying,Li Juane,et al. Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy,2010,25(12):2291-2294.
APA	Guo Xiangyu.,Duan Ying.,Li Juane.,Sun Wen.,Wang Zhicheng.,...&Liu Tonghua.(2010).Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats.China Journal of Traditional Chinese Medicine and Pharmacy,25(12),2291-2294.
MLA	Guo Xiangyu,et al."Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats".China Journal of Traditional Chinese Medicine and Pharmacy 25.12(2010):2291-2294.