Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going | |
Zhang, Jing2; Xiong, Bing1![]() ![]() | |
刊名 | MEDICINAL RESEARCH REVIEWS
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2009-03 | |
卷号 | 29期号:2页码:272-294 |
关键词 | dopamine dopamine receptor benzazepine dihydrexidine Parkinson's disease |
ISSN号 | 0198-6325 |
DOI | 10.1002/med.20130 |
文献子类 | Review |
英文摘要 | The dopamine (DA) D-1 receptor is the most highly expressed DA receptor subtype among the DA receptor family. Although the first DA D-1 receptor selective ligand SCH-23390 (1) was introduced more than two decades ago, clinically useful D-1 receptor selective ligands are rare. A renewed interest was ignited in the early 1990s by Nichols and Mailman who developed dihydrexidine (27a), the first high affinity full efficacy agonist for the D-1 receptor. Since then, a number of D-1 receptor agonists with full intrinsic activity, including A-86929 (31a), dinapsoline (32a), dinoxyline (34a), and doxanthrine (35a) were identified. These compounds all contain a conformationally rigid structure. However, the fate of such ligands for clinical use as treatments of Parkinson's disease and other related CNS disorders is not optimistic since the clinical trial with dihydrexidine (27a) was not successful. Further investigations on other compounds which are currently in the discovery stage will be crucial for determining the future of the D-1 receptor agonists. (C) 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 2, 272-294, 2009 |
资助项目 | Chinese National Science Foundation[306725 17] ; Shanghai Commission of Science and Technology[07pj14104] ; Ministry of Science and Technology[2007AA02z163] ; Shanghai Institute of Materia Medica[00000000] |
WOS关键词 | PROTEIN-COUPLED RECEPTORS ; CONFORMATIONALLY RESTRICTED ANALOGS ; ADENYLATE-CYCLASE ACTIVITY ; COMFA-BASED PREDICTION ; PARKINSONS-DISEASE ; D1 RECEPTOR ; DRUG DISCOVERY ; PHARMACOLOGICAL CHARACTERIZATION ; BETA-PHENYLDOPAMINE ; BINDING-SITE |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000263510600002 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279306] ![]() |
专题 | 药理学第二研究室 药物化学研究室 |
通讯作者 | Zhen, Xuechu |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Discovery Chem Lab, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, SOMCL, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Neuropharmacol Lab, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Jing,Xiong, Bing,Zhen, Xuechu,et al. Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going[J]. MEDICINAL RESEARCH REVIEWS,2009,29(2):272-294. |
APA | Zhang, Jing,Xiong, Bing,Zhen, Xuechu,&Zhang, Ao.(2009).Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going.MEDICINAL RESEARCH REVIEWS,29(2),272-294. |
MLA | Zhang, Jing,et al."Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going".MEDICINAL RESEARCH REVIEWS 29.2(2009):272-294. |
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