Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going

doi:10.1002/med.20130

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going
	Zhang, Jing 2; Xiong, Bing1 ; Zhen, Xuechu 3; Zhang, Ao2
刊名	MEDICINAL RESEARCH REVIEWS
	2009-03
卷号	29 期号:2 页码:272-294
关键词	dopamine dopamine receptor benzazepine dihydrexidine Parkinson's disease
ISSN号	0198-6325
DOI	10.1002/med.20130
文献子类	Review
英文摘要	The dopamine (DA) D-1 receptor is the most highly expressed DA receptor subtype among the DA receptor family. Although the first DA D-1 receptor selective ligand SCH-23390 (1) was introduced more than two decades ago, clinically useful D-1 receptor selective ligands are rare. A renewed interest was ignited in the early 1990s by Nichols and Mailman who developed dihydrexidine (27a), the first high affinity full efficacy agonist for the D-1 receptor. Since then, a number of D-1 receptor agonists with full intrinsic activity, including A-86929 (31a), dinapsoline (32a), dinoxyline (34a), and doxanthrine (35a) were identified. These compounds all contain a conformationally rigid structure. However, the fate of such ligands for clinical use as treatments of Parkinson's disease and other related CNS disorders is not optimistic since the clinical trial with dihydrexidine (27a) was not successful. Further investigations on other compounds which are currently in the discovery stage will be crucial for determining the future of the D-1 receptor agonists. (C) 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 2, 272-294, 2009
资助项目	Chinese National Science Foundation[306725 17] ; Shanghai Commission of Science and Technology[07pj14104] ; Ministry of Science and Technology[2007AA02z163] ; Shanghai Institute of Materia Medica[00000000]
WOS关键词	PROTEIN-COUPLED RECEPTORS ; CONFORMATIONALLY RESTRICTED ANALOGS ; ADENYLATE-CYCLASE ACTIVITY ; COMFA-BASED PREDICTION ; PARKINSONS-DISEASE ; D1 RECEPTOR ; DRUG DISCOVERY ; PHARMACOLOGICAL CHARACTERIZATION ; BETA-PHENYLDOPAMINE ; BINDING-SITE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000263510600002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279306]
专题	药理学第二研究室药物化学研究室
通讯作者	Zhen, Xuechu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Discovery Chem Lab, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, SOMCL, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Neuropharmacol Lab, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jing,Xiong, Bing,Zhen, Xuechu,et al. Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going[J]. MEDICINAL RESEARCH REVIEWS,2009,29(2):272-294.
APA	Zhang, Jing,Xiong, Bing,Zhen, Xuechu,&Zhang, Ao.(2009).Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going.MEDICINAL RESEARCH REVIEWS,29(2),272-294.
MLA	Zhang, Jing,et al."Dopamine D-1 Receptor Ligands: Where Are We Now and Where Are We Going".MEDICINAL RESEARCH REVIEWS 29.2(2009):272-294.