Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

doi:10.1016/j.cell.2011.08.008

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	Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
	Tan, Minjia1 ; Luo, Hao 1; Lee, Sangkyu 1; Jin, Fulai 4,5; Yang, Jeong Soo 1; Montellier, Emilie 2,3,8; Buchou, Thierry 2,3,8; Cheng, Zhongyi 1; Rousseaux, Sophie 2,3,8; Rajagopal, Nisha 4,5
刊名	CELL
	2011-09-16
卷号	146 期号:6 页码:1015-1027
ISSN号	0092-8674
DOI	10.1016/j.cell.2011.08.008
文献子类	Article
英文摘要	We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is mechanistically and functionally different from histone lysine acetylation (Kac). Specifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active promoters or potential enhancers. In male germinal cells immediately following meiosis, Kcr is enriched on sex chromosomes and specifically marks testis-specific genes, including a significant proportion of X-linked genes that escape sex chromosome inactivation in haploid cells. These results therefore dramatically extend the repertoire of histone PTM sites and designate Kcr as a specific mark of active sex chromosome-linked genes in postmeiotic male germ cells.
资助项目	National Institute of Health[00000000] ; INCa-DHOS[00000000] ; ANR blanche "EpiSperm"[00000000] ; ARC[00000000]
WOS关键词	MASS-SPECTROMETRY ; POSTTRANSLATIONAL MODIFICATIONS ; CHROMATIN MODIFICATIONS ; HUMAN-CELLS ; CODE ; DISTINCT ; H3 ; PHOSPHORYLATION ; ACETYLATION ; METHYLATION
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000295258100022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278400]
专题	天然药物化学研究室
通讯作者	Zhao, Yingming
作者单位	1.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA; 2.Univ Grenoble 1, F-38706 La Tronche, France; 3.Fac Med, Inst Albert Bonniot, F-38706 La Tronche, France 4.Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, La Jolla, CA 92093 USA; 5.Univ Calif San Diego, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 7.Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA; 8.INSERM, U823, F-38706 La Tronche, France;
推荐引用方式 GB/T 7714	Tan, Minjia,Luo, Hao,Lee, Sangkyu,et al. Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification[J]. CELL,2011,146(6):1015-1027.
APA	Tan, Minjia.,Luo, Hao.,Lee, Sangkyu.,Jin, Fulai.,Yang, Jeong Soo.,...&Zhao, Yingming.(2011).Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification.CELL,146(6),1015-1027.
MLA	Tan, Minjia,et al."Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification".CELL 146.6(2011):1015-1027.