Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage

doi:10.1002/ardp.201100424

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage
	Tian, Yu 2; Ma, Chao 2; Feng, Linyin1 ; Zhang, Lei 1; Hao, Feiyue 2; Pan, Li 2; Cheng, Maosheng 2
刊名	ARCHIV DER PHARMAZIE
	2012-06
卷号	345 期号:6 页码:423-430
关键词	Cerebral ischemia (-)-Linarinic acid derivatives Neuroprotective effect Oxygen glucose deprivation SH-SY5Y cells
ISSN号	0365-6233
DOI	10.1002/ardp.201100424
文献子类	Article
英文摘要	A series of novel (-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives were designed and synthesized. All of the prepared compounds were screened for their neuroprotective effects using an in vitro oxygen glucose deprivation (OGD) model of ischemic stroke. Some of the target compounds exhibited moderate to excellent protective potency. In particular, compounds 9d, 9e, 9g, and 9h showed significant protective effects in the SH-SY5Y cell line at all three concentrations tested.
资助项目	National Natural Science Foundation of China[30973613]
WOS关键词	OXYGEN-GLUCOSE DEPRIVATION ; CATALYZED REDUCTION ; HYDROGEN-PEROXIDE ; NITRO-COMPOUNDS ; HYDRAZINE ; APOPTOSIS ; ISCHEMIA ; CARBON ; MODEL
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000305123700002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278056]
专题	药理学第二研究室
通讯作者	Cheng, Maosheng
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shenyang Pharmaceut Univ, Key Lab Struct Based Drugs Design & Discovery, Minist Educ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China;
推荐引用方式 GB/T 7714	Tian, Yu,Ma, Chao,Feng, Linyin,et al. Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage[J]. ARCHIV DER PHARMAZIE,2012,345(6):423-430.
APA	Tian, Yu.,Ma, Chao.,Feng, Linyin.,Zhang, Lei.,Hao, Feiyue.,...&Cheng, Maosheng.(2012).Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage.ARCHIV DER PHARMAZIE,345(6),423-430.
MLA	Tian, Yu,et al."Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage".ARCHIV DER PHARMAZIE 345.6(2012):423-430.