Bioactive C-21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole

doi:10.1021/np501058b

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	Bioactive C-21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole
	Li, Jin-Long 3; Zhou, Juan 2; Chen, Zhen-Hua 3; Guo, Sheng-Ya 2; Li, Chun-Qi 1,2; Zhao, Wei-Min3
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-07
卷号	78 期号:7 页码:1548-1555
ISSN号	0163-3864
DOI	10.1021/np501058b
文献子类	Article
英文摘要	Six new C-21 steroidal glycosides, cynotophyllosides A-F (1-6), together with 16 known compounds, were isolated from the roots of Cynanchum otophyllum. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The three major components, otophylloside F (15), otophylloside B (17), and rostratamine 3-O-beta-D-oleandropyranosyl-(1 beta-D-oleandropyranosyl-(1 -> 4)-beta-D-cymaropyranosyl (1 -> 4)-beta-D-cymaropyranoside), suppressed the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. Preliminary structure-activity relation studies revealed that a pregnene skeleton with a C-12 ester group (ikemaoyl > cinnamoyl > hydroxy > p-hydroxybenzoyl) and a C-3 sugar chain consisting of three 2,6-dideoxysaccharide units is essential for this suppressive activity.
资助项目	National Natural Science Foundation of People's Republic of China[81273399]
WOS关键词	(ASCLEPIADACEAE). CHEMICAL-STRUCTURES ; PREGNANE GLYCOSIDES ; EPILEPTIC SEIZURES ; ANTITUMOR-ACTIVITY ; WALLICHII WIGHT ; FRESH STEM ; AURICULATUM ; CAUDATUM ; BEHAVIOR ; MODELS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000358700000010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276474]
专题	天然药物化学研究室
通讯作者	Li, Chun-Qi
作者单位	1.Wenzhou Med Univ, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Zhejiang, Peoples R China 2.Htinter Biotechnol Inc, Hangzhou 311231, Zhejiang, Peoples R China; 3.Chinese Acad Sci, Dept Nat Product Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Li, Jin-Long,Zhou, Juan,Chen, Zhen-Hua,et al. Bioactive C-21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(7):1548-1555.
APA	Li, Jin-Long,Zhou, Juan,Chen, Zhen-Hua,Guo, Sheng-Ya,Li, Chun-Qi,&Zhao, Wei-Min.(2015).Bioactive C-21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole.JOURNAL OF NATURAL PRODUCTS,78(7),1548-1555.
MLA	Li, Jin-Long,et al."Bioactive C-21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole".JOURNAL OF NATURAL PRODUCTS 78.7(2015):1548-1555.