KCNQ potassium channels in sensory system and neural circuits

doi:10.1038/aps.2015.131

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	KCNQ potassium channels in sensory system and neural circuits
	Wang, Jing-jing; Li, Yang
刊名	ACTA PHARMACOLOGICA SINICA
	2016-01
卷号	37 期号:1 页码:25-33
关键词	KCNQ channels M channels neural circuits channelopathy epilepsy neuropathic pain deafness mental illness
ISSN号	1671-4083
DOI	10.1038/aps.2015.131
文献子类	Review
英文摘要	M channels, an important regulator of neural excitability, are composed of four subunits of the Kv7 (KCNQ) K+ channel family. M channels were named as such because their activity was suppressed by stimulation of muscarinic acetylcholine receptors. These channels are of particular interest because they are activated at the subthreshold membrane potentials. Furthermore, neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channels in the sensory system and neural circuits as well as discuss their respective mechanisms and the implications for physiology and medicine. We will also consider future perspectives and the development of additional pharmacological models, such as seizure, stroke, pain and mental illness, which work in combination with drug-design targeting of KCNQ channels. These models will hopefully deepen our understanding of KCNQ channels and provide general therapeutic prospects of related channelopathies.
资助项目	National Natural Science Foundation of China[31128009] ; National Natural Science Foundation of China[31171011] ; National Natural Science Foundation of China[31171066] ; National Natural Science Foundation of China[91413122] ; Ministry of Science and Technology of China[2013CB910601]
WOS关键词	RETINAL-PIGMENT EPITHELIUM ; LONG-TERM POTENTIATION ; FAMILIAL NEONATAL CONVULSIONS ; ACCESSORY OLFACTORY-BULB ; RAT HIPPOCAMPAL SLICES ; OUTER HAIR-CELLS ; K+ CHANNELS ; DOMINANT DEAFNESS ; LANGE-NIELSEN ; HEARING-LOSS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5613573
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000367514700005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276268]
专题	药理学第二研究室
通讯作者	Li, Yang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jing-jing,Li, Yang. KCNQ potassium channels in sensory system and neural circuits[J]. ACTA PHARMACOLOGICA SINICA,2016,37(1):25-33.
APA	Wang, Jing-jing,&Li, Yang.(2016).KCNQ potassium channels in sensory system and neural circuits.ACTA PHARMACOLOGICA SINICA,37(1),25-33.
MLA	Wang, Jing-jing,et al."KCNQ potassium channels in sensory system and neural circuits".ACTA PHARMACOLOGICA SINICA 37.1(2016):25-33.