Design and synthesis of new tetrandrine derivatives and their antitumor activities

doi:10.1080/10286020.2016.1188085

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Design and synthesis of new tetrandrine derivatives and their antitumor activities
	Wei, Xiao 2; Qu, Ting-Li 2; Yang, Yi-Fang 1; Xu, Jin-Fang 2; Li, Xu-Wen3 ; Zhao, Zheng-Bao 2; Guo, Yue-Wei3
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2016
卷号	18 期号:10 页码:966-975
关键词	Tetrandrine Suzuki coupling synthesis antitumor activity structure-activity relationship
ISSN号	1028-6020
DOI	10.1080/10286020.2016.1188085
文献子类	Article
英文摘要	A series of tetrandrine derivatives were designed and synthesized using Suzuki coupling reaction. Eleven targeted compounds with over 50% inhibition against HL60 and A549 human cancer cell lines at 10M were further evaluated for the in vitro antitumor activities by MTT or SRB assay. The biological results revealed that some compounds exhibited potent antitumor activities. Thiophene derivative 6 and acetylphenyl derivative 5 were the most active ones against HL60 and A549 cell lines, with IC50 values less than 5M, which thus could be considered as useful candidate for further development of new antitumor agents.
资助项目	11th Five Plan for Significant Formulation of New Drugs[2009ZX09301-007] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[8130269241476063] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039]
WOS关键词	ACID-ESTER DERIVATIVES ; MULTIDRUG-RESISTANCE ; BISBENZYLISOQUINOLINE ALKALOIDS ; BIOLOGICAL EVALUATION ; APOPTOSIS ; CANCER ; CELLS
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000381494000008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276209]
专题	天然药物化学研究室
通讯作者	Zhao, Zheng-Bao; Guo, Yue-Wei
作者单位	1.Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China; 2.Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wei, Xiao,Qu, Ting-Li,Yang, Yi-Fang,et al. Design and synthesis of new tetrandrine derivatives and their antitumor activities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(10):966-975.
APA	Wei, Xiao.,Qu, Ting-Li.,Yang, Yi-Fang.,Xu, Jin-Fang.,Li, Xu-Wen.,...&Guo, Yue-Wei.(2016).Design and synthesis of new tetrandrine derivatives and their antitumor activities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(10),966-975.
MLA	Wei, Xiao,et al."Design and synthesis of new tetrandrine derivatives and their antitumor activities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.10(2016):966-975.