The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice

doi:10.1007/s00213-016-4292-z

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice
	Wang, Qian 2; Long, Yu 2; Hang, Ai 3; Zan, Gui-Ying 1,4; Shu, Xiao-Hong 2; Wang, Yu-Jun1,4 ; Liu, Jing-Gen1,4
刊名	PSYCHOPHARMACOLOGY
	2016-06
卷号	233 期号:12 页码:2411-2418
关键词	ATPM-ET Emotional response kappa agonist mu partial agonist
ISSN号	0033-3158
DOI	10.1007/s00213-016-4292-z
文献子类	Article
英文摘要	Opioid receptors are implicated in the regulation of motivation and emotion. However, animal studies show that activation of kappa opioid receptor produces contrasting mood-altering effects in models of anxiety-like and depressive-like behaviors, and consequently, the role of kappa receptor in mood control remains unsettled. The effect of kappa/mu opioid combination in emotion regulation was unexplored. The aim of the study was to investigate the effects of (-)-3-N-ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride (ATPM-ET), a novel kappa agonist and mu partial agonist, in regulating emotional responses. The emotional responses of ATPM-ET were detected in the elevated plus maze (EPM), open field test (OFT), forced swim test (FST), and tail suspension test (TST). Selective kappa antagonist nor-binaltorphimine (nor-BNI) and mu antagonist beta-funaltrexamine (beta-FNA) were applied to determine the type of receptor involved. The conditioned place aversion model was used to evaluate the effects on aversive emotion. In the EPM and OFT, ATPM-ET (1 and 2 mg/kg, s.c.) significantly increased the time spent in the open arm and in the central area, respectively. In the FST and TST, ATPM-ET (0.5 and 1 mg/kg, s.c.) significantly reduced the duration of immobility. These effects were prevented by nor-BNI (10 mg/kg, i.p., -24 h), but not by beta-FNA (10 and20 mg/kg, i.p., -24 h) pretreatment. At the dose of 2 mg/kg, ATPM-ET did not induce conditioned place aversion. ATPM-ET, at doses from 0.5 to 2 mg/kg, produced anxiolytic- and antidepressant-like effects without inducing aversive emotion. These effects were more closely mediated by activation of kappa receptor than mu receptor.
资助项目	Ministry of Science and Technology of China[2013CB835100] ; Ministry of Science and Technology of China[2015CB553500] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; National Natural Science Foundation of China[81401107] ; Committee of Science and Technology of Shanghai[13JC140680]
WOS关键词	OPIOID RECEPTOR ANTAGONISTS ; TAIL-SUSPENSION TEST ; ANXIETY-LIKE BEHAVIOR ; RATS ; DEPRESSION ; MODELS ; SYSTEM ; STRESS ; BUPRENORPHINE ; DYNORPHIN
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000376410800018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276027]
专题	药理学第二研究室
通讯作者	Shu, Xiao-Hong; Wang, Yu-Jun
作者单位	1.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China 2.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China; 3.Shanghai Inst Food & Drug Control, Dept Pharmacol & Toxicol, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Qian,Long, Yu,Hang, Ai,et al. The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice[J]. PSYCHOPHARMACOLOGY,2016,233(12):2411-2418.
APA	Wang, Qian.,Long, Yu.,Hang, Ai.,Zan, Gui-Ying.,Shu, Xiao-Hong.,...&Liu, Jing-Gen.(2016).The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice.PSYCHOPHARMACOLOGY,233(12),2411-2418.
MLA	Wang, Qian,et al."The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice".PSYCHOPHARMACOLOGY 233.12(2016):2411-2418.