kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice

doi:10.1016/j.neuropharm.2016.04.022

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice
	Wang, Yu-Jun1,5 ; Hang, Ai 2,3; Lu, Yu-Chen 1,5; Long, Yu 4; Zan, Gui-Ying 1,5; Li, Xue-Ping 1,5; Wang, Qian 4; Zhao, Zeng-Xiang 1,5; He, Ling 3; Chi, Zhi-Qiang1,5
刊名	NEUROPHARMACOLOGY
	2016-11
卷号	110 页码:92-101
关键词	kappa Opioid receptor pERK1/2 Region-specific Dual effects Anxiety
ISSN号	0028-3908
DOI	10.1016/j.neuropharm.2016.04.022
文献子类	Article
英文摘要	kappa Opioid receptor system is widely implicated in the regulation of emotion. However, the findings about the role on anxiety in rodents are highly controversial, since both anxiogenic- and anxiolytic-like effects have been reported with kappa opioid receptor activation. The mechanism and the underlying neuroanatomical substrates are unexplored. In the present study, we first investigated the effects of kappa agonist U50,488H on anxiety-related behaviors over a wide range of doses, and we found that U50,488H produced dual effects in anxiety, with low dose being anxiogenic and high dose being anxiolytic. To assess the potential neuroanatomical substrates, we used phosphorylation of extracellular signal-related kinasel /2 (pERK1/2) to map the underlying neural circuits. We found that the anxiogenic effect of U50,488H was paralleled by an increase of pERK1/2 in the nucleus accumbens, whereas the anxiolytic effect was paralleled by an increase of pERK1/2 in the lateral septa] nucleus. We then examined the behavioral consequences with locally microinjection of U50,488H, and we found that microinjection of U50,488H into the nucleus accumbens exerted anxiogenic-like effects, whereas microinjection of U50,488H into the lateral septa] nucleus. Both effects can be abolished by kappa antagonist nor-BNI pretreatment. To the best of our knowledge, the present work firstly provides the neuroanatomical sites that mediating the dual anxiogenic- and anxiolytic-like effects of U50,488H in mice. This study may help to explain current controversial role of kappa receptor activation in anxiety-related behaviors in rodents, and may open new perspectives in the areas of anxiety disorders and K receptor function. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	Ministry of Science and Technology of China[2013CB835100] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; National Natural Science Foundation of China[81401107] ; Committee of Science and Technology of Shanghai[13JC140680]
WOS关键词	ELEVATED PLUS-MAZE ; ELEMENT-BINDING PROTEIN ; NUCLEUS-ACCUMBENS ; SALVIA-DIVINORUM ; GUINEA-PIG ; STRESS ; AMYGDALA ; SYSTEM ; DEPRESSION ; KINASE
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000385318100009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275841]
专题	药理学第二研究室
通讯作者	Liu, Jing-Gen
作者单位	1.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China; 2.Shanghai Inst Food & Drug Control, Dept Pharmacol & Toxicol, Shanghai 201203, Peoples R China; 3.China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China; 4.Dalian Med Univ, Dept Pharm, Dalian 116044, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Yu-Jun,Hang, Ai,Lu, Yu-Chen,et al. kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice[J]. NEUROPHARMACOLOGY,2016,110:92-101.
APA	Wang, Yu-Jun.,Hang, Ai.,Lu, Yu-Chen.,Long, Yu.,Zan, Gui-Ying.,...&Liu, Jing-Gen.(2016).kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice.NEUROPHARMACOLOGY,110,92-101.
MLA	Wang, Yu-Jun,et al."kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice".NEUROPHARMACOLOGY 110(2016):92-101.