Suppression of lipopolysaccharide-induced impairment of active avoidance and interleukin-6-induced increase of prostaglandin E-2 release in rats by indometacin

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	Suppression of lipopolysaccharide-induced impairment of active avoidance and interleukin-6-induced increase of prostaglandin E-2 release in rats by indometacin
	Ma, TC; Zhu, XZ
刊名	ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
	1997-05
卷号	47 期号:5 页码:595-597
关键词	anti-inflammatories, non-steroidal CAS53-81-1 indometacin, in vivo studies pharmacology interleukin-6 lipopolysaccharides prostaglandin E-2 release, hippocampal
ISSN号	0004-4172
文献子类	Article
英文摘要	The effects of indometacin (CAS 53-86-1) on lipopolysaccharide-induced impairment of active avoidance and on interleukin-6-induced increase of prostaglandin E-2 release were investigated in rats. In the experiment on acquisition and retention of one-way active avoidance in a shuttle box model, bilateral infusion of lipopolysaccharides (LPS) into the hippocampus, 1 mu g per side, resulted in a significant impairment both in acquisition and retention by prolonging the latency of avoidance in training and testing. In the meantime, intraperitoneal injection of indometacin 10 mg/kg daily for 7 days, improved the LPS-induced amnesia especially in the testing by shortening the latency from 2.3 to 1.7 s (p < 0.05). In the in vivo microdialysis study in anesthetized rats, intrahippocampal infusion of 80 ng interleukin-6 (IL-6) markedly increased prostaglandin E-2(PGE(2)) release into hippocampal dialysates which started at 2 h post administration. Perfusion of indometacin (0.3 mol/l) into the hippocampus for 1 h obviously suppressed the IL-6-induced PGE(2) response. These findings provide experimental evidence that - assuming that central inflammation may be involved with Alzheimer's disease a non-steroidal anti-inflammatory drug may be used in the treatment of Alzheimer's disease.
WOS关键词	NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ALZHEIMERS-DISEASE ; CYTOKINES ; INDUCTION ; BRAIN ; MICE
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
WOS记录号	WOS:A1997XD52900002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274914]
专题	药理学第二研究室
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	Ma, TC,Zhu, XZ. Suppression of lipopolysaccharide-induced impairment of active avoidance and interleukin-6-induced increase of prostaglandin E-2 release in rats by indometacin[J]. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH,1997,47(5):595-597.
APA	Ma, TC,&Zhu, XZ.(1997).Suppression of lipopolysaccharide-induced impairment of active avoidance and interleukin-6-induced increase of prostaglandin E-2 release in rats by indometacin.ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH,47(5),595-597.
MLA	Ma, TC,et al."Suppression of lipopolysaccharide-induced impairment of active avoidance and interleukin-6-induced increase of prostaglandin E-2 release in rats by indometacin".ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH 47.5(1997):595-597.