Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity

doi:10.1016/S0008-6215(01)00238-5

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity
	Bao, XF; Duan, JY; Fang, XY; Fang, JN
刊名	CARBOHYDRATE RESEARCH
	2001-11-08
卷号	336 期号:2 页码:127-140
关键词	Ganoderma lucidum (1 -> 3)-alpha-D-glucan chemical modification immunological activity
ISSN号	0008-6215
DOI	10.1016/S0008-6215(01)00238-5
文献子类	Article
英文摘要	A linear (1 --> 3)-alpha -D-glucan was isolated from the spores of Ganoderma lucidum (Fr.) Karst. Six different functionalized derivatives of the (1 --> 3)-alpha -D-glucan-aminopropylated, hydroxyethylated, sulfated, carboxymethylated, carboxymethylated and sulfated, and benzylamidated-carboxymethylated-with varying degrees of substitution were synthesized. The structural features and physicochemical properties of all derivatives were investigated by means of chemical and spectral analyses, and their effects on lymphocyte proliferation and antibody production were tested in vitro and in vivo. In general, the structural and physicochemical properties, and lymphocyte proliferation activity of all samples varied with the functionalized groups and the degree of substitution. The results of immunological assays indicated that some modified derivatives had potent stimulating effects on lymphocyte proliferation and antibody production and the introduction of carboxymethyl group with low degree of substitution (DS < 0.28) was the best choice on the improvement of the immunostimulating activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
WOS关键词	ANTITUMOR-ACTIVITY ; DERIVATIVES ; POLYSACCHARIDES ; (1->3)-BETA-D-GLUCANS ; BEHAVIOR ; GLUCAN
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000172090100005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274430]
专题	药理学第三研究室天然药物化学研究室
通讯作者	Fang, JN
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Bao, XF,Duan, JY,Fang, XY,et al. Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity[J]. CARBOHYDRATE RESEARCH,2001,336(2):127-140.
APA	Bao, XF,Duan, JY,Fang, XY,&Fang, JN.(2001).Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity.CARBOHYDRATE RESEARCH,336(2),127-140.
MLA	Bao, XF,et al."Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity".CARBOHYDRATE RESEARCH 336.2(2001):127-140.