Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis

doi:10.1016/j.ejphar.2004.12.020

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	Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis
	Wang, LZ; Sun, WC; Zhu, XZ
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2005-01-31
卷号	508 期号:1-3 页码:57-68
关键词	Parkinson's disease dopamine ethyl pyruvate oxidative stress nuclear transcription factor kappa B p53
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2004.12.020
文献子类	Article
英文摘要	Pyruvate acid can protect cells against oxidative damage. However, its instability limits its usefulness as a therapeutic agent. In this study, we examined the effect of ethyl pyruvate, an aliphatic ester derived from pyruvate acid, on dopamine-induced cytotoxicity in rat pheochromocytoma PC12 cells. The results demonstrated that dopamine induced apoptosis in PC12 cells accompanied with increases of intercellular reactive oxygen species, nuclear translocation of nuclear transcription factor kappa B (NF-kappaB) and expression of p53 and decrease of mitochondrial transmembrane potential. Ethyl pyruvate markedly reduced the dopamine-induced production of reactive oxygen species, nuclear translocation of NF-kappaB, upregulation of p53, loss of mitochondrial transmembrane potential and apoptosis in PC12 cells. The results suggested that ethyl pyruvate might protect PC12 cells against dopamine by suppressing intercellular oxidative stress and modulating key signal pathways of apoptosis, and that ethyl pyruvate might be used as a potential therapeutic agent for Parkinson's disease. (C) 2004 Elsevier B.V. All rights reserved.
WOS关键词	NF-KAPPA-B ; CENTRAL-NERVOUS-SYSTEM ; ROTENONE-INDUCED APOPTOSIS ; BCL-2 FAMILY PROTEINS ; TUMOR-SUPPRESSOR P53 ; PARKINSONS-DISEASE ; BRAIN MITOCHONDRIA ; HYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; SH-SY5Y CELLS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000226894000007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273937]
专题	药理学第二研究室
通讯作者	Zhu, XZ
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, LZ,Sun, WC,Zhu, XZ. Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2005,508(1-3):57-68.
APA	Wang, LZ,Sun, WC,&Zhu, XZ.(2005).Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis.EUROPEAN JOURNAL OF PHARMACOLOGY,508(1-3),57-68.
MLA	Wang, LZ,et al."Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis".EUROPEAN JOURNAL OF PHARMACOLOGY 508.1-3(2005):57-68.