A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease | |
Huang, J; Liu, HQ; Gu, WW![]() ![]() ![]() | |
刊名 | BIOMATERIALS
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2006-02 | |
卷号 | 27期号:6页码:937-946 |
关键词 | Parkinson's disease rotenone microspheres PLGA drug delivery |
ISSN号 | 0142-9612 |
DOI | 10.1016/j.biomaterials.2005.07.005 |
文献子类 | Article |
英文摘要 | In order to study the pathogenesis of Parkinson's disease (PD), and explore therapeutic drug or approaches, the accurate animal model of PD with inexpensive, biocompatible and convenient administration was necessary. The aim of the present work was to investigate a delivery strategy for rotenone microspheres in an animal model of PD. The rotenone microspheres were prepared by solvent evaporation technique. The rotenone microspheres showed high entrapment efficiency (97.4 +/- 2.2%) with particle size about 100 mu m. In vitro release of rotenone microspheres demonstrated different profiles from medium with different pH or concentration of isopropyl alcohol. The most consistent medium with in vivo rotenone levels in rat plasma was PBS (pH 5.8) with 20% isopropyl alcohol, and the cumulated release amount of rotenone over 30 days was 95.4% in it. The rotenone microspheres (90 mg/kg) produced typical PD symptoms in rats, for example, the cataleptic behavior test demonstrated a obviously prolonged descent latency compared with control animals after administration, and the tyrosine hydroxylase (TH) immunohistochemistry tests showed typical histological evidence of selective degeneration of the nigrostriatal dopaminergic system (striatum and substantia nigra) in rotenone micro spheres-treated rats. In addition, this delivery system for rotenone model showed many noticeable advantages such as inexpensive, biocompatible and expedient administration by direct subcutaneous injection. This information suggested that rotenone microspheres as a delivery strategy for setting up an ideal animal model of PD was feasible. (c) 2005 Elsevier Ltd. All rights reserved. |
WOS关键词 | IN-VITRO RELEASE ; SYMPTOMS ; RATS ; FTIR |
WOS研究方向 | Engineering ; Materials Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000234095800014 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/273671] ![]() |
专题 | 药理学第二研究室 药物制剂研究中心 |
通讯作者 | Li, YP |
作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, J,Liu, HQ,Gu, WW,et al. A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease[J]. BIOMATERIALS,2006,27(6):937-946. |
APA | Huang, J.,Liu, HQ.,Gu, WW.,Yan, Z.,Xu, ZH.,...&Li, YP.(2006).A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease.BIOMATERIALS,27(6),937-946. |
MLA | Huang, J,et al."A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease".BIOMATERIALS 27.6(2006):937-946. |
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