Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT

doi:10.1016/j.phytochem.2017.10.012

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	Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT
	Wang, Wan-Ping 2,3; Jiang, Kun 3; Zhang, Ping 4; Shen, Kai-Kai 1; Qu, Shi-Jin3 ; Yu, Xiao-Ping 4; Tan, Chang-Heng3
刊名	PHYTOCHEMISTRY
	2018-01
卷号	145 页码:93-102
关键词	Euphorbia helioscopia Euphorbiaceae Diterpenoids Substituent effects Ent-abietane Ent-kaurane Lathyrane
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2017.10.012
文献子类	Article
英文摘要	A phytochemical investigation on the aerial part of Euphorbia helioscopia ( Euphorbiaceae) led to the isolation of 22 highly oxygenated diterpenoids with structural types of ent-abietane, ent-kaurane, lathyrane, ent-atisane and ingenane. 17 of them, named euphelionolides A - N, 16-epi-18-hydroxy-abbeokutone, as well as eupheliotriols A and B, were identified to be previously undescribed compounds by extensive analysis of spectroscopic data. The stereostructures of euphelionolides A - K were determined by single crystal X-ray diffraction combined with analysis of substituent effects and comparison of optical characteristics. Eupheliotriol B is the first example of natural occurring lathyrol with 12Z-ene, while ent-atisanes are the first reported from the title plant. Furthermore, euphelionolides F and L exhibited significant cytotoxicity against MCF-7 and PANC-1 cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	"Personalized Medicines - Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences, P. R. China[XDA12040315]
WOS关键词	CALYPTRATA CELL-CULTURES ; EUPHORBIA-HELIOSCOPIA ; JATROPHANE DITERPENOIDS ; DENDROIDES ; LATHYRIS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000423245300011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272343]
专题	天然药物化学研究室
通讯作者	Tan, Chang-Heng
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Nanchang Univ, Med Coll, Dept Pharm, Nanchang 330006, Jiangxi, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Wan-Ping,Jiang, Kun,Zhang, Ping,et al. Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT[J]. PHYTOCHEMISTRY,2018,145:93-102.
APA	Wang, Wan-Ping.,Jiang, Kun.,Zhang, Ping.,Shen, Kai-Kai.,Qu, Shi-Jin.,...&Tan, Chang-Heng.(2018).Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT.PHYTOCHEMISTRY,145,93-102.
MLA	Wang, Wan-Ping,et al."Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT".PHYTOCHEMISTRY 145(2018):93-102.