The fatty acids of the green alga Caulerpa racemosa and their bioactivities

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	The fatty acids of the green alga Caulerpa racemosa and their bioactivities
	Liu Dingquan 2; Li Jia1 ; Zhang Haiyan1 ; Feng Meitang 2; Yang Hui 2; Yang Peng 2; Lin Kun 2; GU〇 Yuewei 1; Mao Shuichun 2
刊名	Chinese Journal of Marine Drugs
	2013
卷号	32 期号:6 页码:13-20
关键词	Caulerpa racemosa fatty acids neuro-protective activity PTP1B inhibitory activity
ISSN号	1002-3461
其他题名	中国南海总状蕨藻的脂肪酸类化学成分和生物活性研究
文献子类	Article
英文摘要	Objective To isolate and identify fatty acids of the green alga Caulerpa racemosa (ForsskAl) J. Agardh from the South China Sea and to evaluate their biological activities. Methods Compounds were isolated by means of various chromatographic techniques including silica gel and Sephadex LH-20 column chromatography and reverse phase HPLC. Their structures were elucidated on the basis of spectroscopic analysis including lD NMR, MS,and optical rotation. All of the isolates were evaluated for their inhibitory activity against PTP1B by enzyme-labelled method and neuro-protective activity against OGD-, H_2 0_2-,Alphabeta_(25-35)-caused damage on SH-SY5Y cells by MTT method. Results Twelve known fatty acids and related derivatives were isolated and identified as palmitic acid (1), stearic acid (2),diethyl octadecanedioate (3),glycerin monotricosanate (4),(8E)-heptadec-8-en-7-one (5),(8Z, 11Z)-heptadeca-8,11-dienoic acid (6),ethyl linolenoate (7),(4Z,7Z,10Z,13Z)-ethyl hexadeca-4,7,10, 13-tetraenoate (8),beta-dimorphecolic acid (9),beta-dimorphecolic acid -(10),(9R,10E, 12Z)-9-hydroxyoctadeca-10,12-dienoic acid (11),and (9R, 10E)-9-hydroxyoctadec-10-enoic acid (12),respectively. Conclusions Compound 5 was first discovered as a natural product. Moreover, except for compounds 1 and 2, this is the first report that described the isolation of all of compounds from Caulerpa racemosa, of which 3,4, and 8-12 were obtained for the first time from marine organisms and 6 and 7 were first isolated from the genus Caulerpa. Compound 2 moderately attenuated the OGD (oxygen-glucose deprivation)-induced SH-SY5Y cell damage with 9. 87% increase in cell viability at the concentration of 10 muMu,while 5 also showed moderate neuro-protective activity against the Abeta_(25-35)-induced SH-SY5Y cell damage (6. 28% increase at 10 muM). Compounds 1,2,5,11,and 12 exhibited potent PTP1B inhibitory activity with IC50 values of 5. 390. 55,14. 781. 85,47. 403. 57, 40. 343. 28,and 35. 23 2. 65 muMu, respectively.
资助项目	国家自然科学基金[00000000] ; 江西省青年科学家培养对象计划[00000000] ; 江西省自然科学基金[00000000] ; 江西省教育厅课题[00000000] ; 教育部留学回国人员科研启动基金资助[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5030616
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269357]
专题	国家新药筛选中心药理学第二研究室药物安全性评价中心
作者单位	1.State key laboratory of Drug Research,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Nanchang University, Nanchang, Jiangxi 330006, China.;
推荐引用方式 GB/T 7714	Liu Dingquan,Li Jia,Zhang Haiyan,et al. The fatty acids of the green alga Caulerpa racemosa and their bioactivities[J]. Chinese Journal of Marine Drugs,2013,32(6):13-20.
APA	Liu Dingquan.,Li Jia.,Zhang Haiyan.,Feng Meitang.,Yang Hui.,...&Mao Shuichun.(2013).The fatty acids of the green alga Caulerpa racemosa and their bioactivities.Chinese Journal of Marine Drugs,32(6),13-20.
MLA	Liu Dingquan,et al."The fatty acids of the green alga Caulerpa racemosa and their bioactivities".Chinese Journal of Marine Drugs 32.6(2013):13-20.