Diversity-oriented synthesis and its application in drug discovery

	Diversity-oriented synthesis and its application in drug discovery
	Zhang Lei; Zheng Mingyue; Liu Hong
刊名	Acta Pharmaceutica Sinica
	2015
卷号	50 期号:4 页码:419-433
关键词	diversity-oriented synthesis diversity chemical space compound library drug discovery
ISSN号	0513-4870
其他题名	多样性合成及其在药物发现中的应用
文献子类	Review
英文摘要	Diversity-oriented synthesis (DOS)aims to efficiently generate collections of small molecules with diverse appendages, functional groups, stereochemistry and skeletons, thus yielding diverse biological activities capable of modulating a wide variety of biological processes. In this review, we discussed the common strategies employed in DOS with specific examples from recent literature, including reagent-based approach, substrate-based approach, build-couple-pair strategy and privileged substructure-based DOS. The application of some DOS libraries in drug discovery is also presented.
资助项目	国家杰出青年科学基金项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5388138
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269290]
专题	药物化学研究室药理学第二研究室
通讯作者	Liu Hong
作者单位	Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Zhang Lei,Zheng Mingyue,Liu Hong. Diversity-oriented synthesis and its application in drug discovery[J]. Acta Pharmaceutica Sinica,2015,50(4):419-433.
APA	Zhang Lei,Zheng Mingyue,&Liu Hong.(2015).Diversity-oriented synthesis and its application in drug discovery.Acta Pharmaceutica Sinica,50(4),419-433.
MLA	Zhang Lei,et al."Diversity-oriented synthesis and its application in drug discovery".Acta Pharmaceutica Sinica 50.4(2015):419-433.