Synthesis of taxoids against multidrug resistant tumor cells

	Synthesis of taxoids against multidrug resistant tumor cells
	Zhang Shujun 2; Shen Jingshan2 ; Wang Jinlan 3; Ji Ruyun 2; Ando Masayoshi 1
刊名	Chinese Journal New Drugs
	2005
卷号	14 期号:5 页码:579
关键词	taxinine NN-3 taxinine NN-14 laxinine biological activity against multidrug resistant (MDR) taxinine NN-3 laxinine NN-14
ISSN号	1003-3734
其他题名	MDR逆转活性紫杉烷类化合物的合成
文献子类	Article
英文摘要	Objective:To synthesize taxinine NN-3 and taxinine NN-14 with biological activity against multidrug resistant (MDR) tumor cells. Methods; Starting from taxinine, taxinine NN-3 and taxinine NN-14 were synthesized via selective deacetoxylation ,orthoester and hydrolysis. Results : Total yield of taxinine NN-14 was 68% and taxinine NN-4 was 25% from taxinine. Conclusion: A simple and yielding synthesis of taxinine NN-3 and taxinine NN-14 was achieved.
资助项目	中国科学院王宽诚博士后基金[00000000] ; 上海市博士后基金[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2034196
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268294]
专题	药物化学研究室
通讯作者	Shen Jingshan
作者单位	1.Department of Chemistry and Engineering, Niigata University, Niigata 950-2181, Japan. 2.Shangliai Institute of Materiu Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Department of Chemistry and Qiemical Engineering, Qiqihar University, Qiqihar, Heilongjiang 161006, China.;
推荐引用方式 GB/T 7714	Zhang Shujun,Shen Jingshan,Wang Jinlan,et al. Synthesis of taxoids against multidrug resistant tumor cells[J]. Chinese Journal New Drugs,2005,14(5):579.
APA	Zhang Shujun,Shen Jingshan,Wang Jinlan,Ji Ruyun,&Ando Masayoshi.(2005).Synthesis of taxoids against multidrug resistant tumor cells.Chinese Journal New Drugs,14(5),579.
MLA	Zhang Shujun,et al."Synthesis of taxoids against multidrug resistant tumor cells".Chinese Journal New Drugs 14.5(2005):579.