Studies on Treatment of Menopausal Syndrome with Angeng Capsules

	Studies on Treatment of Menopausal Syndrome with Angeng Capsules
	FANG Liang 1; WEI Xiaohui 2; HE Qiaojun 1; LUO Peihua 1; FAN Lingling 1; YANG Bo 1; SHEN Jingshan2
刊名	Chinese Pharmaceutical Journal
	2006
卷号	41 期号:22 页码:1741-1744
关键词	angeng capsules menopausal syndrome phaimacodynamics
ISSN号	1001-2494
其他题名	安更胶囊治疗女性更年期综合征的药效学研究
文献子类	Article
英文摘要	To evaluate the pre-clinical effect of Angeng capsules on treatment of menopausal syndrome in mice and rat models. METHODS The sleep enhancement action with pentobarbital sodium (PS) was observed in pre-treated mice model.Trie analgesic effect was observed with writhing test.Antidiaphoresis action was observed with pilocarpine in pre-LreaLed mice model.The antidepressant action was evaluated with forced swimming test and tail suspension test.The effect on the serum level of estradiol, androgen, LH and FSH was determined in castrated female rat. RESULTS Angeng capsules (> 0.41 g·kg~(-1)) significantly enhanced the sleeping time in mice pre-treated with PS. When the close was above 1.65 g·kg~(-1), Angeng capsules significantly reduced the frequency of writhing and diaphoresis; Angeng capsules (>3.3 g·kg~(-1)) significantly increased swimming time in forced swimming test and moving time in tail suspension test. Angeng capsules showed no significant effect on the E2, T and FSH level in rat serum, but made a significant decline of LH level in the serum. CONCLUSION Angeng capsules can promote sleep, exert antidepressant, antifatigue and analgesic effect, and inhibit the secretion of sweat glands without decreasing serum estrodial level. It's a promising anti-menopausal syndrome Chinese herbal medicine.
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2657542
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268203]
专题	药物化学研究室
作者单位	1.Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, China.; 2.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	FANG Liang,WEI Xiaohui,HE Qiaojun,et al. Studies on Treatment of Menopausal Syndrome with Angeng Capsules[J]. Chinese Pharmaceutical Journal,2006,41(22):1741-1744.
APA	FANG Liang.,WEI Xiaohui.,HE Qiaojun.,LUO Peihua.,FAN Lingling.,...&SHEN Jingshan.(2006).Studies on Treatment of Menopausal Syndrome with Angeng Capsules.Chinese Pharmaceutical Journal,41(22),1741-1744.
MLA	FANG Liang,et al."Studies on Treatment of Menopausal Syndrome with Angeng Capsules".Chinese Pharmaceutical Journal 41.22(2006):1741-1744.