Improved synthesis of resveratrol

	Improved synthesis of resveratrol
	Zhou Y　(周宇　); Li J　(李剑　); Li J　(李建　); 赵临襄　 ; Jiang HL(蒋华良); Liu H(柳红)
刊名	Chinese Journal of Medicinal Chemistry
	2008
卷号	18 期号:6 页码:429-433
关键词	resveratrol procedure improvement Wittig-Horner reaction
ISSN号	1005-0108
其他题名	扎那米韦的合成工艺研究
文献子类	Article
英文摘要	Aim To study the synthesis of resveratrol.Methods The target compound was prepared from 3,5-dihydroxybenzoic acid by methylation and reduction,followed by bromination and reaction with triethyl phosphate to give diethyl(3,5-dimethoxybenzyl)phosphonate,then condensation with anisaldehyde and deprotection with AlCl3.Results and conclusion The overall yield was 39%.The improved procedure can be easily operated and is suitable to scale production.In addition,the starting materials are conveniently obtained.
资助项目	National Key Technology R&D Programof China(Grant 2006BAI01B02)[00000000] ; the 863 Hi-Tech Program(Grants 2006AA020602,2006AA02Z336)[00000000] ; the Key Project for New Drug Re-search from CAS[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	英语
CSCD记录号	CSCD:3444936
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268063]
专题	药物化学研究室
通讯作者	Liu H(柳红)
作者单位	1.The Center for Drug Discovery and Design,Shanghai Institute of Materia Medics, Chinese Academy of Sciences, Shanghai 201203, China.; 2.School of Pharmaceutical Engineering,Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. 3.School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.;
推荐引用方式 GB/T 7714	Zhou Y　,Li J　,Li J　,et al. Improved synthesis of resveratrol[J]. Chinese Journal of Medicinal Chemistry,2008,18(6):429-433.
APA	周宇　,李剑　,李建　,赵临襄　,蒋华良,&柳红.(2008).Improved synthesis of resveratrol.Chinese Journal of Medicinal Chemistry,18(6),429-433.
MLA	周宇　,et al."Improved synthesis of resveratrol".Chinese Journal of Medicinal Chemistry 18.6(2008):429-433.