Modulated interaction of mu/delta opioid receptors and the drug discovery and design strategy

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Modulated interaction of mu/delta opioid receptors and the drug discovery and design strategy
	SHEN Qing 2; LIU Hui-fang 2; LI Wei 2; LI Ying 3; CHENG Jia-gao 4; LIU Jing-gen1 ; FU Wei 2
刊名	Chinese Pharmacological Bulletin
	2010
卷号	26 期号:1 页码:4-8
关键词	mu/delta agonist mu agonist/delta antagonist opioid analgesics drug design low addiction dual action
ISSN号	1001-1978
其他题名	mu/delta阿片受体相互调节作用及药物发现与设计策略
文献子类	Review
英文摘要	Opioid analgesics are potent pain-killer and are widely used in clinical practice.Opioid receptors are classified into mu,delta,kappa subtypes.Most of the currently available opioid analgesics are mu opioid receptor agonists, but they cause undesired side effects such as physical dependence, respiratory depression and constipation and so on.The antalgic activity of delta receptor agonist is weaker than that of mu agonist, but it can modulate the activity of mu receptor and prevent its addiction. Therefore, discovering and designing compounds with mu/delta dual action is a new way for finding analgesics with low toxicity and less side effects.This review summarizes the development of compound with dual mu/delta activities and provides a new strategy for designing analgesics with low toxicity and less side effects.
资助项目	国家自然科学基金资助课题[00000000] ; 博士点新教师基金资助课题[00000000] ; 上海市卫生局资助项目[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3829278
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267939]
专题	药理学第二研究室
作者单位	1.Shanghai Institute of Materia Medica, Shanghai 201203, China. 2.Dept of Medicinal Chemistry,School of Pharmacy, Fudan University, Shanghai 201203, China.; 3.Dept of Metallurgy and Materials,Inner Mongolia Vocational College of Machine-Electrical Engineering, Hohhot, Inner Mongolia 010051, China.; 4.School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.;
推荐引用方式 GB/T 7714	SHEN Qing,LIU Hui-fang,LI Wei,et al. Modulated interaction of mu/delta opioid receptors and the drug discovery and design strategy[J]. Chinese Pharmacological Bulletin,2010,26(1):4-8.
APA	SHEN Qing.,LIU Hui-fang.,LI Wei.,LI Ying.,CHENG Jia-gao.,...&FU Wei.(2010).Modulated interaction of mu/delta opioid receptors and the drug discovery and design strategy.Chinese Pharmacological Bulletin,26(1),4-8.
MLA	SHEN Qing,et al."Modulated interaction of mu/delta opioid receptors and the drug discovery and design strategy".Chinese Pharmacological Bulletin 26.1(2010):4-8.