Effect of baicalin on serum glucose, cholesterol and activation of AMPK in streptozotocin-induced type 2 diabetic rats

	Effect of baicalin on serum glucose, cholesterol and activation of AMPK in streptozotocin-induced type 2 diabetic rats
	Liu Jinfeng; Peng Hongli
刊名	Chinese Journal of Pharmacology and Toxicology
	2011
卷号	25 期号:2 页码:145-150
关键词	baicalin diabetes mellitus, type 2 protein kinases adenylate kinase oxidative stress
ISSN号	1000-3002
其他题名	黄芩苷对链脲佐菌素诱导的糖尿病模型大鼠血糖和血脂及腺苷酸活化蛋白激酶的影响
文献子类	Article
英文摘要	OBJECTIVE To investigate the effect of baicalin on streptozocin(STZ)-induced diabetic rats with hyperlipidemia. METHODS Male SD rats were fed with high-fat diet(HFD) 6 weeks and iv given STZ 45 mg·kg-1 to induce a type 2 diabetes model. Baicalin was ip given 80 mg·kg-1 once daily for 6 weeks. Body mass was measured. The serum glucose, total cholesterol(TC) and triglyceride, liver TC and malondialdehyde(MDA) were analyzed. AMP-activated protein kinase(AMPK) activation in the liver and muscle was examined by measuring AMPK phosphorylation and quantitating phosphorylation of AMPK substrate acetyl-CoA carboxylase(ACC). Effects of baicalin on activation of AMPK in HepG2 cells were also examined. RESULTS Baicalin 80 mg·kg-1 suppressed serum glucose and TC concentrations in diabetic rats. Baicalin reduced hepatic TC and MDA(P<0.05) and enhanced phosphorylation of AMPK and ACC(P<0.01).In HepG2 cells, baicalin 1 and 5 mumol·L-1 increased phosphorylation of AMPK(P<0.01).CONCLUSIONBaicalin has protective effects on the development of diabetes by targeting the hepatic and muscular AMPK
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	General & Internal Medicine ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4165353
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267885]
专题	药物化学研究室
通讯作者	Peng Hongli
作者单位	State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Liu Jinfeng,Peng Hongli. Effect of baicalin on serum glucose, cholesterol and activation of AMPK in streptozotocin-induced type 2 diabetic rats[J]. Chinese Journal of Pharmacology and Toxicology,2011,25(2):145-150.
APA	Liu Jinfeng,&Peng Hongli.(2011).Effect of baicalin on serum glucose, cholesterol and activation of AMPK in streptozotocin-induced type 2 diabetic rats.Chinese Journal of Pharmacology and Toxicology,25(2),145-150.
MLA	Liu Jinfeng,et al."Effect of baicalin on serum glucose, cholesterol and activation of AMPK in streptozotocin-induced type 2 diabetic rats".Chinese Journal of Pharmacology and Toxicology 25.2(2011):145-150.