Progresses on prion proteins

	Progresses on prion proteins
	LIN DongHai 1; WEN Yi 2
刊名	Scientia Sinica Chimica
	2011
卷号	41 期号:4 页码:683-698
关键词	transmissible spongiform encephalopathies prion conformational conversion
ISSN号	1674-7224
其他题名	朊病毒蛋白prion的研究进展
文献子类	Review
英文摘要	Transmissible spongiform encephalopathies are a family of fatal neurodegenerative disorders.The pathogen has been identified as the abnormal isoform of the host-derived prion protein.The molecular mechanism of the conformational conversion of the prion protein is unclear so far.However,much valuable information closely related to the conformational change has been obtained by means of physical,chemical and biological techniques.Recent progresses on three-dimensional structures,dynamics,unfolding and intermolecular interactions of prion proteins are reviewed herein,together with novel results about the solution structure and dynamics of the rabbit prion protein achieved from our laboratory.
资助项目	国家自然科学基金[00000000] ; 上海市优秀学科带头人计划[00000000] ; 中国科学院知识创新工程重要方向项目[00000000] ; 国家重点基础研究发展计划973蛋白质重大研究计划项目[00000000]
WOS研究方向	Microbiology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4268347
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267879]
专题	分析化学研究室
作者单位	1.Laboratory of Structural Biology,Department of Chemical Biology,College of Chemistry & Chemical Engineering,Xiamen University, Xiamen, Fujian 361005, China.; 2.Bio-NMR Laboratory,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	LIN DongHai,WEN Yi. Progresses on prion proteins[J]. Scientia Sinica Chimica,2011,41(4):683-698.
APA	LIN DongHai,&WEN Yi.(2011).Progresses on prion proteins.Scientia Sinica Chimica,41(4),683-698.
MLA	LIN DongHai,et al."Progresses on prion proteins".Scientia Sinica Chimica 41.4(2011):683-698.