Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms

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	Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms
	Ye Chunyan; Zhang Haiyan
刊名	Chinese Journal of New Drugs and Clinical Remedies
	2012
卷号	31 期号:12 页码:701-706
关键词	Alzheimer disease mitochondria huperzine A cholinesterase inhibitors
ISSN号	1007-7669
其他题名	石杉碱甲改善阿尔采末病相关线粒体功能损伤及潜在分子机制
文献子类	Article
英文摘要	Alzheimer's disease (AD) is a common neurodegenerative disease, of which the most widely used therapeutic drug is acetylcholinesterase inhibitor (AChEI). Huperzine A, an alkaloid developed by Chinese scientists, is a potent AChEI.Recent work reveals that besides the acetylcholinesterase inhibitory effect, huperzine A can also significantly benefit mitochondria in various models like middle cerebral artery occlusion (MCAO) rat, APP/PSl transgenic mice and beta - amyloid (Alphabeta) injured isolated mitochondria. This review summarizes the pivotal roles of mitochondria in AD processing and the protective effects of huperzine A against AD associated mitochondrial dysfunction, and also discusses the underlying molecular mechanisms of above beneficial effects.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4751097
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267802]
专题	药理学第二研究室
通讯作者	Zhang Haiyan
作者单位	State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, SHANGHAI 201203, China.
推荐引用方式 GB/T 7714	Ye Chunyan,Zhang Haiyan. Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms[J]. Chinese Journal of New Drugs and Clinical Remedies,2012,31(12):701-706.
APA	Ye Chunyan,&Zhang Haiyan.(2012).Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms.Chinese Journal of New Drugs and Clinical Remedies,31(12),701-706.
MLA	Ye Chunyan,et al."Ameliorative effects of huperzine A on Alzheimer'sdisease associated mitochondrial dysfunction and its potential molecular mechanisms".Chinese Journal of New Drugs and Clinical Remedies 31.12(2012):701-706.