Molecular mechanisms and function of intracellular GABA_A receptor transportation | |
Tang Jianxing1; Wang Weisheng2; Ji Hui1; Liu Jinggen2![]() | |
刊名 | Journal of China Pharmaceutical University
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2013 | |
卷号 | 44期号:2页码:182-187 |
关键词 | GABA_A receptors receptor trafficking somnipathy epilepsy drug abuse |
ISSN号 | 1000-5048 |
其他题名 | gamma-氨基丁酸A型受体转运的胞内调节机制及其功能研究进展 |
文献子类 | Review |
英文摘要 | Inhibition of the central nervous system (CNS) is mainly mediated by GABAergic neurons, its nervous transmission is important for all aspects of CNS function. The effects of central GABAergic system are mainly mediated by both GABA_A receptors, which belong to the superfamily of heteropentameric ligand-gated ion channels, and GABA_B receptors, which belong to superfamily of G-protein coupled heptahelical transmembrane receptors. Fast synaptic inhibition in the mammalian brain is mainly mediated by GABA_A receptors. In this chapter, we summarized recent findings on the molecular mechanisms of intracellular transportation and functions of GABA_A receptors, and discussed the regulating roles of post-translational modifications, GABA_A receptors associated proteins, scaffold proteins, enzymes etc in this process. Finally, we highlighted a number of neuropsychical diseases, in which confusion of GABA_A receptors trafficking occured. |
资助项目 | 国家重点基础研究发展计划("九七三计划)资助项目[00000000] ; "十二五国家科技支撑计划重大专项资助项目[00000000] |
WOS研究方向 | Pharmacology & Pharmacy ; General & Internal Medicine (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:4816352 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/267782] ![]() |
专题 | 药理学第二研究室 |
作者单位 | 1.Department of Pharmacology,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; 2.State Key Laboratory of New Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
推荐引用方式 GB/T 7714 | Tang Jianxing,Wang Weisheng,Ji Hui,et al. Molecular mechanisms and function of intracellular GABA_A receptor transportation[J]. Journal of China Pharmaceutical University,2013,44(2):182-187. |
APA | Tang Jianxing,Wang Weisheng,Ji Hui,&Liu Jinggen.(2013).Molecular mechanisms and function of intracellular GABA_A receptor transportation.Journal of China Pharmaceutical University,44(2),182-187. |
MLA | Tang Jianxing,et al."Molecular mechanisms and function of intracellular GABA_A receptor transportation".Journal of China Pharmaceutical University 44.2(2013):182-187. |
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