Molecular mechanisms and function of intracellular GABA_A receptor transportation

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Molecular mechanisms and function of intracellular GABA_A receptor transportation
	Tang Jianxing 1; Wang Weisheng 2; Ji Hui 1; Liu Jinggen2
刊名	Journal of China Pharmaceutical University
	2013
卷号	44 期号:2 页码:182-187
关键词	GABA_A receptors receptor trafficking somnipathy epilepsy drug abuse
ISSN号	1000-5048
其他题名	gamma-氨基丁酸A型受体转运的胞内调节机制及其功能研究进展
文献子类	Review
英文摘要	Inhibition of the central nervous system (CNS) is mainly mediated by GABAergic neurons, its nervous transmission is important for all aspects of CNS function. The effects of central GABAergic system are mainly mediated by both GABA_A receptors, which belong to the superfamily of heteropentameric ligand-gated ion channels, and GABA_B receptors, which belong to superfamily of G-protein coupled heptahelical transmembrane receptors. Fast synaptic inhibition in the mammalian brain is mainly mediated by GABA_A receptors. In this chapter, we summarized recent findings on the molecular mechanisms of intracellular transportation and functions of GABA_A receptors, and discussed the regulating roles of post-translational modifications, GABA_A receptors associated proteins, scaffold proteins, enzymes etc in this process. Finally, we highlighted a number of neuropsychical diseases, in which confusion of GABA_A receptors trafficking occured.
资助项目	国家重点基础研究发展计划("九七三计划)资助项目[00000000] ; "十二五国家科技支撑计划重大专项资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy ; General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4816352
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267782]
专题	药理学第二研究室
作者单位	1.Department of Pharmacology,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; 2.State Key Laboratory of New Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Tang Jianxing,Wang Weisheng,Ji Hui,et al. Molecular mechanisms and function of intracellular GABA_A receptor transportation[J]. Journal of China Pharmaceutical University,2013,44(2):182-187.
APA	Tang Jianxing,Wang Weisheng,Ji Hui,&Liu Jinggen.(2013).Molecular mechanisms and function of intracellular GABA_A receptor transportation.Journal of China Pharmaceutical University,44(2),182-187.
MLA	Tang Jianxing,et al."Molecular mechanisms and function of intracellular GABA_A receptor transportation".Journal of China Pharmaceutical University 44.2(2013):182-187.