PKCs promotes ceramide-induced apoptosis in PC12 cells by decreasing the ratio of Bcl2/Bax involved in a Ca~(2+)- dependent pathway and NF-κB activation

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	PKCs promotes ceramide-induced apoptosis in PC12 cells by decreasing the ratio of Bcl2/Bax involved in a Ca~(2+)- dependent pathway and NF-κB activation
	Jin DZ(金道忠); Zhu XZ(朱兴族)
	2005-10-01
关键词	ceramide PKC Bcl2 Bax Ca2+ IκB
卷号	21
页码	1
英文摘要	This study investigated the rele of PKCs on ceramide-induced apoptosis in Rat phaeochromocytoma PC 12 cells. Exogenous C6-ceramide induced apoptosis in PC 12 cells in a concentration-dependent way (5-20μmol/L). It failed to change the anti-apoptosis protein Bc12 and proapoptosis protein Bax expression at 12 h. Phorbol 12-myristate 13-acetate (PMA), a PKCs activator, failed to change the survive of PC12
会议录	中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会论文摘要汇编
文献子类	Article
语种	英语
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267570]
专题	药理学第二研究室
推荐引用方式 GB/T 7714	Jin DZ,Zhu XZ. PKCs promotes ceramide-induced apoptosis in PC12 cells by decreasing the ratio of Bcl2/Bax involved in a Ca~(2+)- dependent pathway and NF-κB activation[C]. 见:.