Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer

doi:10.1186/1752-0509-7-S3-S6

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物发现与设计中心

	Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer
	Tang, Yifei 1; Yan, Wenying 1; Chen, Jiajia 1; Luo, Cheng1,2 ; Kaipia, Antti 3; Shen, Bairong 1
刊名	BMC SYSTEMS BIOLOGY
	2013-10-16
卷号	7
ISSN号	1752-0509
DOI	10.1186/1752-0509-7-S3-S6
文献子类	Article; Proceedings Paper
英文摘要	Background: MicroRNAs (miRNAs) are potential regulators that contribute to the pathogenesis of cancer. Microarray technologies have been widely used to characterize aberrant miRNA expression patterns in cancer. Nevertheless, the miRNAs expression signatures identified for a same cancer differs among laboratories due to the cancer heterogeneity. In addition, how the deregulated miRNAs coordinately contribute to the tumourigenic process of prostate cancer remains elusive. Results: We evaluated five outlier detection algorithms that take into account the heterogeneity of cancer samples. ORT was selected as the best method and applied to four prostate cancer associated microRNA expression datasets. After microRNA target prediction and pathway enrichment mapping, 38 Gene Ontology terms, 16 KEGG pathways and 99 GeneGO pathways are found putative prostate cancer associated. Comparison with our previous studies, we identified two putative novel pathways important in prostate cancer. The two novel pathways are 1) ligand-independent activation of ESR1 and ESR2 and 2) membrane-bound ESR1: interaction with growth factors signalling. Conclusions: We proved that expression signatures of at the pathway level well address the cancer heterogeneity and are more consistent than at the miRNA/gene levels. Based on this observation, we identified putative novel microRNA regulatory pathways which will help us to elucidate the cooperative function of different microRNAs in prostate cancer.
资助项目	National Natural Science Foundation of China[91230117] ; National Natural Science Foundation of China[31170795] ; Specialized Research Fund for the Doctoral Program of Higher Education of China[20113201110015] ; International S&T Cooperation Program of Suzhou[SH201120] ; National High Technology Research and Development Program of China (863 program)[2012AA02A601]
WOS关键词	DIFFERENTIAL GENE-EXPRESSION ; NEUROTROPHIN RECEPTOR P75(NTR) ; STEM-CELLS ; ACTIVIN-A ; GROWTH ; METASTASIS ; PREDICTION ; MIGRATION ; REVEALS ; KEGG
WOS研究方向	Mathematical & Computational Biology
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000326808300006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277419]
专题	药物发现与设计中心
通讯作者	Shen, Bairong
作者单位	1.Soochow Univ, Ctr Syst Biol, Suzhou 215006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 200031, Peoples R China; 3.Tampere Univ Hosp, Dept Urol, Tamper 33521, Finland
推荐引用方式 GB/T 7714	Tang, Yifei,Yan, Wenying,Chen, Jiajia,et al. Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer[J]. BMC SYSTEMS BIOLOGY,2013,7.
APA	Tang, Yifei,Yan, Wenying,Chen, Jiajia,Luo, Cheng,Kaipia, Antti,&Shen, Bairong.(2013).Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer.BMC SYSTEMS BIOLOGY,7.
MLA	Tang, Yifei,et al."Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer".BMC SYSTEMS BIOLOGY 7(2013).