Versatile solid modifications of icariin: structure, properties and form transformation | |
Jia, Lina1,2; Zhang, Qi2; Wang, Jian-Rong2![]() ![]() | |
刊名 | CRYSTENGCOMM
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2015 | |
卷号 | 17期号:39页码:7500-7509 |
ISSN号 | 1466-8033 |
DOI | 10.1039/c5ce01422k |
文献子类 | Article |
英文摘要 | A comprehensive solid-state screening experiment was performed for icariin (ICA), an active substance in Traditional Chinese Medicine (TCM) which has long been used to treat osteroporosis. Two new polymorphs in their pure forms and ten different solvate modifications were obtained and the single crystal structures were successfully determined. The isostructural phenomenon was readily observed among various organic solvates. Notably, the single crystal structure of the marketed hydrate form H1 was determined for the first time through a single crystal-single crystal transformation (SCSCT) process. The physicochemical properties of various solid forms were further studied. The results show that the newly discovered pure form a presents better thermal stability, lower hygroscopicity and higher solubility compared to the currently marketed form. The superior physicochemical properties render a better drug development ability for this widely applied TCM. |
资助项目 | National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B[00000000] |
WOS关键词 | POLYMORPHISM ; ISOSTRUCTURALITY ; DESOLVATION ; TRANSITION ; HUPERZINE ; STABILITY ; HYDRATION ; CRYSTALS |
WOS研究方向 | Chemistry ; Crystallography |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000362351900010 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276703] ![]() |
专题 | 药物质量控制与固体化学研究中心 |
通讯作者 | Jia, Lina |
作者单位 | 1.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Jia, Lina,Zhang, Qi,Wang, Jian-Rong,et al. Versatile solid modifications of icariin: structure, properties and form transformation[J]. CRYSTENGCOMM,2015,17(39):7500-7509. |
APA | Jia, Lina,Zhang, Qi,Wang, Jian-Rong,&Mei, Xuefeng.(2015).Versatile solid modifications of icariin: structure, properties and form transformation.CRYSTENGCOMM,17(39),7500-7509. |
MLA | Jia, Lina,et al."Versatile solid modifications of icariin: structure, properties and form transformation".CRYSTENGCOMM 17.39(2015):7500-7509. |
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