Versatile solid modifications of icariin: structure, properties and form transformation

doi:10.1039/c5ce01422k

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Versatile solid modifications of icariin: structure, properties and form transformation
	Jia, Lina 1,2; Zhang, Qi 2; Wang, Jian-Rong2 ; Mei, Xuefeng2
刊名	CRYSTENGCOMM
	2015
卷号	17 期号:39 页码:7500-7509
ISSN号	1466-8033
DOI	10.1039/c5ce01422k
文献子类	Article
英文摘要	A comprehensive solid-state screening experiment was performed for icariin (ICA), an active substance in Traditional Chinese Medicine (TCM) which has long been used to treat osteroporosis. Two new polymorphs in their pure forms and ten different solvate modifications were obtained and the single crystal structures were successfully determined. The isostructural phenomenon was readily observed among various organic solvates. Notably, the single crystal structure of the marketed hydrate form H1 was determined for the first time through a single crystal-single crystal transformation (SCSCT) process. The physicochemical properties of various solid forms were further studied. The results show that the newly discovered pure form a presents better thermal stability, lower hygroscopicity and higher solubility compared to the currently marketed form. The superior physicochemical properties render a better drug development ability for this widely applied TCM.
资助项目	National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B[00000000]
WOS关键词	POLYMORPHISM ; ISOSTRUCTURALITY ; DESOLVATION ; TRANSITION ; HUPERZINE ; STABILITY ; HYDRATION ; CRYSTALS
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000362351900010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276703]
专题	药物质量控制与固体化学研究中心
通讯作者	Jia, Lina
作者单位	1.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jia, Lina,Zhang, Qi,Wang, Jian-Rong,et al. Versatile solid modifications of icariin: structure, properties and form transformation[J]. CRYSTENGCOMM,2015,17(39):7500-7509.
APA	Jia, Lina,Zhang, Qi,Wang, Jian-Rong,&Mei, Xuefeng.(2015).Versatile solid modifications of icariin: structure, properties and form transformation.CRYSTENGCOMM,17(39),7500-7509.
MLA	Jia, Lina,et al."Versatile solid modifications of icariin: structure, properties and form transformation".CRYSTENGCOMM 17.39(2015):7500-7509.