Recent progress in natural products as DPP-4 inhibitors | |
Gao, Yuanyuan3; Zhang, Yong1; Zhu, Jianming1; Li, Bo1; Li, Zhao3; Zhu, Weiliang1![]() | |
刊名 | FUTURE MEDICINAL CHEMISTRY
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2015 | |
卷号 | 7期号:8页码:1079-1089 |
ISSN号 | 1756-8919 |
DOI | 10.4155/FMC.15.49 |
文献子类 | Review |
英文摘要 | Diabetes mellitus is a chronic disease affecting patients' daily life and increasing patients' risk of other complication. Dipeptidyl peptidase-4 (DPP-4) is a serine aminopeptidase, which is one of the validated targets for Type 2 diabetes therapy due to its regulatory effect of incretin hormone. Seven DPP-4 inhibitors are commercially available nowadays on the market as Type 2 diabetes drugs. They are all chemically synthesized compounds with good therapeutic effects, but long-term safety remains unknown. On the other hand, nature provides a rich source for search of desired safe and effective medications; and actually more than half of the drugs on market are natural product related. Therefore, a systematic search for new DPP-4 inhibitors from nature sources seems to be of great utility for developing novel antidiabetic drugs. This review summarized recent progress of DPP-4 inhibitors from natural products, revealed that both pure natural products and the crude extracts of herbs or the hydrolyzates of proteins are active as DPP-4 inhibitors. Therefore, both could be served as useful clues for developing next generation of antidiabetes medicines via inhibiting DPP-4 activity. |
资助项目 | Natural Science Foundation of Shanghai, China[15ZR1441200] ; Shanghai Municipal Education Commission[2013JW09] |
WOS关键词 | DIPEPTIDYL-PEPTIDASE-IV ; BETA-LACTOGLOBULIN ; IN-VITRO ; BERBERINE ; EXTRACTS |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | FUTURE SCI LTD |
WOS记录号 | WOS:000362890300009 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276701] ![]() |
专题 | 药物发现与设计中心 |
通讯作者 | Jia, Qi |
作者单位 | 1.Chinese Acad Sci, Drug Discovery & Design Ctr, ACS Key Lab Membrane Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.UCB Pharma, Dept Informat, Slough SL1 4EN, Berks, England 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; |
推荐引用方式 GB/T 7714 | Gao, Yuanyuan,Zhang, Yong,Zhu, Jianming,et al. Recent progress in natural products as DPP-4 inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(8):1079-1089. |
APA | Gao, Yuanyuan.,Zhang, Yong.,Zhu, Jianming.,Li, Bo.,Li, Zhao.,...&Li, Yiming.(2015).Recent progress in natural products as DPP-4 inhibitors.FUTURE MEDICINAL CHEMISTRY,7(8),1079-1089. |
MLA | Gao, Yuanyuan,et al."Recent progress in natural products as DPP-4 inhibitors".FUTURE MEDICINAL CHEMISTRY 7.8(2015):1079-1089. |
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