Recent progress in natural products as DPP-4 inhibitors

doi:10.4155/FMC.15.49

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物发现与设计中心

	Recent progress in natural products as DPP-4 inhibitors
	Gao, Yuanyuan 3; Zhang, Yong 1; Zhu, Jianming 1; Li, Bo 1; Li, Zhao 3; Zhu, Weiliang1 ; Shi, Jiye 2; Jia, Qi 3; Li, Yiming 3
刊名	FUTURE MEDICINAL CHEMISTRY
	2015
卷号	7 期号:8 页码:1079-1089
ISSN号	1756-8919
DOI	10.4155/FMC.15.49
文献子类	Review
英文摘要	Diabetes mellitus is a chronic disease affecting patients' daily life and increasing patients' risk of other complication. Dipeptidyl peptidase-4 (DPP-4) is a serine aminopeptidase, which is one of the validated targets for Type 2 diabetes therapy due to its regulatory effect of incretin hormone. Seven DPP-4 inhibitors are commercially available nowadays on the market as Type 2 diabetes drugs. They are all chemically synthesized compounds with good therapeutic effects, but long-term safety remains unknown. On the other hand, nature provides a rich source for search of desired safe and effective medications; and actually more than half of the drugs on market are natural product related. Therefore, a systematic search for new DPP-4 inhibitors from nature sources seems to be of great utility for developing novel antidiabetic drugs. This review summarized recent progress of DPP-4 inhibitors from natural products, revealed that both pure natural products and the crude extracts of herbs or the hydrolyzates of proteins are active as DPP-4 inhibitors. Therefore, both could be served as useful clues for developing next generation of antidiabetes medicines via inhibiting DPP-4 activity.
资助项目	Natural Science Foundation of Shanghai, China[15ZR1441200] ; Shanghai Municipal Education Commission[2013JW09]
WOS关键词	DIPEPTIDYL-PEPTIDASE-IV ; BETA-LACTOGLOBULIN ; IN-VITRO ; BERBERINE ; EXTRACTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FUTURE SCI LTD
WOS记录号	WOS:000362890300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276701]
专题	药物发现与设计中心
通讯作者	Jia, Qi
作者单位	1.Chinese Acad Sci, Drug Discovery & Design Ctr, ACS Key Lab Membrane Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.UCB Pharma, Dept Informat, Slough SL1 4EN, Berks, England 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Gao, Yuanyuan,Zhang, Yong,Zhu, Jianming,et al. Recent progress in natural products as DPP-4 inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(8):1079-1089.
APA	Gao, Yuanyuan.,Zhang, Yong.,Zhu, Jianming.,Li, Bo.,Li, Zhao.,...&Li, Yiming.(2015).Recent progress in natural products as DPP-4 inhibitors.FUTURE MEDICINAL CHEMISTRY,7(8),1079-1089.
MLA	Gao, Yuanyuan,et al."Recent progress in natural products as DPP-4 inhibitors".FUTURE MEDICINAL CHEMISTRY 7.8(2015):1079-1089.