Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1

doi:10.1002/ejoc.201403678

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	Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1
	Chen, Chunmei 1; Zhu, Hucheng 1; Wang, Jianping 1; Yang, Jing 2,3; Li, Xiao-Nian 2; Wang, Jing 1; Chen, Keliang 1; Wang, Yanyan 4,5; Luo, Zengwei 1; Yao, Guangmin 1
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2015-05
期号	14 页码:3086-3094
关键词	Natural products Drug discovery Antiviral agents Polycycles Structure elucidation
ISSN号	1434-193X
DOI	10.1002/ejoc.201403678
文献子类	Article
英文摘要	Eight rare pyrrole-based cytochalasans, termed armochaetoglobins K-R (1-8), along with three known analogues (9-11), were isolated from the solid culture broth of Chaetomium globosum TW1-1, a symbiotic fungus derived from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated using a combination of spectroscopic analysis, a single-crystal X-ray diffraction experiment, and an electronic circular dichroism (ECD) calculation. Compounds 4-8 represent the first examples of chaetoglobosin-type cytochalasans with an sp(3) methine carbon at C-18. All of the isolates were evaluated for their anti-HIV activities in vitro, and compounds 2-4, 7, 8, and 10 showed significant anti-HIV activities, with EC50 values ranging from 0.11 to 0.55 mu M, and selectivity index (SI) values ranging from 12.33 to 75.42. A plausible biosynthetic pathway was proposed to explain the origin of the pyrrole ring.
资助项目	State Education Ministry of China, Program for New Century Excellent Talents in University[NCET-2008-0224] ; National Natural Science Foundation of China (NSFC)[31370372] ; National Natural Science Foundation of China (NSFC)[31200258] ; National Natural Science Foundation of China (NSFC)[31270395] ; National Natural Science Foundation of China (NSFC)[81202423] ; National Science and Technology Project of China[2011ZX09102-004]
WOS关键词	CYTOTOXIC CYTOCHALASANS ; ENDOPHYTIC FUNGUS ; CHAETOGLOBOSIN ; BIOSYNTHESIS ; METABOLITES ; SKELETON ; AGENT ; CELLS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000354212000015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276548]
专题	药物发现与设计中心
通讯作者	Xue, Yongbo
作者单位	1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang 443003, Peoples R China; 5.Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China
推荐引用方式 GB/T 7714	Chen, Chunmei,Zhu, Hucheng,Wang, Jianping,et al. Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(14):3086-3094.
APA	Chen, Chunmei.,Zhu, Hucheng.,Wang, Jianping.,Yang, Jing.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2015).Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(14),3086-3094.
MLA	Chen, Chunmei,et al."Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .14(2015):3086-3094.