Selective crystallization of vitamin D-3 for the preparation of novel conformational polymorphs with distinctive chemical stability

doi:10.1039/c5ce02431e

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Selective crystallization of vitamin D-3 for the preparation of novel conformational polymorphs with distinctive chemical stability
	Wang, Jian-Rong; Zhu, Bingqing; Yu, Qihui; Mei, Xuefeng
刊名	CRYSTENGCOMM
	2016
卷号	18 期号:7 页码:1101-1104
ISSN号	1466-8033
DOI	10.1039/c5ce02431e
文献子类	Article
英文摘要	A new conformational polymorph of VD3 containing a pure a conformer was prepared and fully characterized. Chemical stability and hygroscopicity are compared with the marketed solid-state form (form A, two conformers alpha/beta, 1 : 1). The results indicate that crystallization of VD3 needs to be controlled to avoid the unstable polymorph.
资助项目	National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; CAS Key Technology Talent Program[00000000] ; Youth Innovation Promotion Association CAS[00000000]
WOS关键词	SOLID-STATE NMR ; 1-ALPHA,25-DIHYDROXYVITAMIN-D3 ; COCRYSTAL ; FORMS
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000369670800003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276248]
专题	药物质量控制与固体化学研究中心
通讯作者	Mei, Xuefeng
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jian-Rong,Zhu, Bingqing,Yu, Qihui,et al. Selective crystallization of vitamin D-3 for the preparation of novel conformational polymorphs with distinctive chemical stability[J]. CRYSTENGCOMM,2016,18(7):1101-1104.
APA	Wang, Jian-Rong,Zhu, Bingqing,Yu, Qihui,&Mei, Xuefeng.(2016).Selective crystallization of vitamin D-3 for the preparation of novel conformational polymorphs with distinctive chemical stability.CRYSTENGCOMM,18(7),1101-1104.
MLA	Wang, Jian-Rong,et al."Selective crystallization of vitamin D-3 for the preparation of novel conformational polymorphs with distinctive chemical stability".CRYSTENGCOMM 18.7(2016):1101-1104.