A computer model for the pore of potassium channel: Oxygen cage mechanism

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	A computer model for the pore of potassium channel: Oxygen cage mechanism
	Zhao, SR; Chen, KX; Tang, Y; Wang, W; Ji, RY
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	1997-05
卷号	29 期号:3 页码:229-234
关键词	potassium ion channel molecular modeling pore-forming region membrane protein
ISSN号	0582-9879
文献子类	Article
英文摘要	We have constructed a structural motif for the pore of voltage-gated Kf channel by computer modeling. The model developed here predicts that the narrowest part of the pore is formed by the four carbonyl oxygens of Gly444 or Gly446, and that the ion selectivity is achieved through ''oxygen cage'' mechanism. Residues 447,448 and 449 make the external entrance to the narrowest part of the pore. Of these residues, 449 and 447 are believed to interact directly with TEA. This model agrees well with many available experimental data.
WOS关键词	SHAKER K+ CHANNEL ; RESIDUES ; CHARYBDOTOXIN ; INHIBITOR ; PEPTIDE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	中文
CSCD记录号	CSCD:392329
出版者	SHANGHAI INST BIOCHEMISTRY, ACADEMIA SINICA
WOS记录号	WOS:A1997XZ28400002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274910]
专题	药物发现与设计中心药理学第二研究室
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	Zhao, SR,Chen, KX,Tang, Y,et al. A computer model for the pore of potassium channel: Oxygen cage mechanism[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,1997,29(3):229-234.
APA	Zhao, SR,Chen, KX,Tang, Y,Wang, W,&Ji, RY.(1997).A computer model for the pore of potassium channel: Oxygen cage mechanism.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,29(3),229-234.
MLA	Zhao, SR,et al."A computer model for the pore of potassium channel: Oxygen cage mechanism".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 29.3(1997):229-234.