The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island
	Li Songwei 8; Yao Ligong 4; Liang Linfu 7; Guo Yuewei1
刊名	Chinese Journal of Marine Drugs
	2018
卷号	37 期号:4 页码:1-6
关键词	soft coral steroids cytotoxicity
ISSN号	1002-3461
其他题名	西瑁岛软珊瑚Sinulariasp.的化学成分和生物活性研究
文献子类	Article
英文摘要	Objective To study the chemical constituents and bioactivities of soft coral sinulariasp.collected from Ximao Island in South China Sea.Methods The isolation and purification of these compounds were performed by TLC,silica gel,Sephadex LH-20 column chromatography and semi-preparative HPLC.Their structures were characterized by analysis of NMR and MS data and comparison with the data reported in literatures.The cytotoxicity of these compoundsagainst A549 and HL-60 cell lines hasbeen tested by using Cell Counting Kit-8(CCK-8)method.Results Ten known steroids were isolated from the soft coral sinulariasp.and their structures were identified as pregna-5,20-dien-3beta-O-acetate( 1),pregna-20-en-3-one(2),pregna-1,20-dien-3-one(3),pregna-1,4,20-trien-3-one(4),pregna- 20-en-3beta-ol(5),pregna-5,20-dien-3beta-ol(6),pregna-1,4-dien-3-one-20alpha-O-acetate(7),alpha-galactopyranoside- 3beta-pregna-5,20-dien-3-yl-6-deoxy(8),(22E,24R)- ergosta-7,22-dien-3beta,5alpha,6beta-triol(9)and (20S)- 20-hydroxy cholost-1,4-dien-3,16-dione(10).Conclusion Though compounds 1~10 didn'texhibit potent cytotoxicity against A549 cell lines,compounds 4 and 7 showed moderate cytotoxicity against HL-60 cell lines with IC_(50) values of 1.61 and 3.26mumol/L,respectively.
资助项目	国家自然科学基金项目[00000000] ; 国家自然科学基金山东联合基金项目[00000000] ; 上海市科委基金项目[00000000] ; 新药研究国家重点实验室项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6308104
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269158]
专题	天然药物化学研究室
通讯作者	Guo Yuewei
作者单位	1.Shanghai Institute of MateriaMedica, Chinese Academy of Sciences; 2.Nanchang; 3.; 4.Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China.; 5.Shanghai 6.State Key Laboratory of Drug Research; 7.College of Materials Science and Engineering,Central South University of Forestry and Technology, Changsha, Hunan 410004, China.; 8.School of Pharmacy,Nanchang University; 9.Chinese Academy of Sciences,;
推荐引用方式 GB/T 7714	Li Songwei,Yao Ligong,Liang Linfu,et al. The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island[J]. Chinese Journal of Marine Drugs,2018,37(4):1-6.
APA	Li Songwei,Yao Ligong,Liang Linfu,&Guo Yuewei.(2018).The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island.Chinese Journal of Marine Drugs,37(4),1-6.
MLA	Li Songwei,et al."The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island".Chinese Journal of Marine Drugs 37.4(2018):1-6.