Research progress of anti-influenza virus agents

	Research progress of anti-influenza virus agents
	ZHANG Qiang; ZHAO Qing-jie; XIONG Rui-sheng; LI Jian-feng; SHEN Jing-shen
刊名	Acta Pharmaceutica Sinica
	2010
卷号	45 期号:3 页码:289-299
关键词	anti-influenza virus agent M2 protein ion channel inhibitor arbidol hydrochloride neuraminidase inhibitor
ISSN号	0513-4870
其他题名	抗流感病毒药物研究进展
文献子类	Review
英文摘要	Influenza is a major threat to millions of people worldwide.Vaccines and aativiral agents are two main options available to reduce the impact of the influenza virus,while anti-influenza agents are the most effective means to prevent the transmission of the highly contagious virus and to treat the epidemics of disease.At present,four anti-influenza agents have been approved by the FDA for the treatment of influenza,including two M2 protein ion channel inhibitors-amantadine and rimantadine and two neuraminidase inhibitors-zanamivir and oseltamivir.Arbidol hydrochloride,launched in Russia,is a pcltent inhibitor of influenza virus,too.Neuraminidase inhibitors could be classified generally by structure into six different kinds:sialic acid derivatives,benzoic acid derivatives,cyclohexene derivatives,cyclopentane derivatives,pyrrolidine derivatives and natural products.In this paper,recent progress in the research of the action mechanisms and structure-activity relationships of these anti-influenza virus agents were reviewed.
资助项目	上海市科委国际科技合作基金[00000000] ; 国家科技部支撑计划资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3824695
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267963]
专题	药物化学研究室药物质量控制与固体化学研究中心药理学第一研究室药物安全性评价中心
通讯作者	SHEN Jing-shen
作者单位	Shanghai Institute of Materia Medica,Chinese Academy of Science, Shanghai 201203, China.
推荐引用方式 GB/T 7714	ZHANG Qiang,ZHAO Qing-jie,XIONG Rui-sheng,et al. Research progress of anti-influenza virus agents[J]. Acta Pharmaceutica Sinica,2010,45(3):289-299.
APA	ZHANG Qiang,ZHAO Qing-jie,XIONG Rui-sheng,LI Jian-feng,&SHEN Jing-shen.(2010).Research progress of anti-influenza virus agents.Acta Pharmaceutica Sinica,45(3),289-299.
MLA	ZHANG Qiang,et al."Research progress of anti-influenza virus agents".Acta Pharmaceutica Sinica 45.3(2010):289-299.