From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions

doi:10.1002/anie.201712618

	From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions
	Wang, Dong-Yu 2,3,4; Yang, Ze-Kun 1,5; Wang, Chao 1,5; Zhang, Ao2,3,4,6 ; Uchiyama, Masanobu 1,5
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018-03-26
卷号	57 期号:14 页码:3641-3645
关键词	amines C-N cleavage C-O formation ethers late-stage functionalization
ISSN号	1433-7851
DOI	10.1002/anie.201712618
文献子类	Article
英文摘要	We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe3+), which are readily prepared from anilines (ArNR2, R=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as (KOBu)-Bu-t or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR2. It is scalable and compatible with a wide range of functional groups.
资助项目	Chinese NSF[81773565] ; Chinese NSF[81430080] ; Chinese NSF[21702216] ; National Program on Key Basic Research Project of China[2015CB910603] ; International Cooperative Program[GJHZ1622] ; Chinese Academy of Sciences[160621] ; Shanghai Commission of Science and Technology[16XD1404600] ; Shanghai Commission of Science and Technology[14431905300] ; Shanghai Commission of Science and Technology[14431900400] ; SA-SIBS Scholarship Program[00000000] ; China Postdoctoral Science Foundation[00000000] ; JSPS[17H05430] ; JSPS KAKENHI[17H06173] ; Kobayashi International Scholarship Foundation[00000000] ; YakuGaku ShinKoKai Foundation[00000000] ; RIKEN[00000000]
WOS关键词	N BOND-CLEAVAGE ; QUATERNARY AMMONIUM-SALTS ; CATALYZED CROSS-COUPLINGS ; CARBON-NITROGEN BONDS ; C-N ; ALKYL-ARYL ; ROOM-TEMPERATURE ; REAGENTS ; BORYLATION ; FUNCTIONALIZATION
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000428350100016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279840]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Chao; Zhang, Ao; Uchiyama, Masanobu
作者单位	1.RIKEN, Elements Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 5.Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dong-Yu,Yang, Ze-Kun,Wang, Chao,et al. From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3641-3645.
APA	Wang, Dong-Yu,Yang, Ze-Kun,Wang, Chao,Zhang, Ao,&Uchiyama, Masanobu.(2018).From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3641-3645.
MLA	Wang, Dong-Yu,et al."From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3641-3645.