Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla

doi:10.3390/md16040103

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	Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla
	Ye, Fei 1,3; Zhu, Zheng-Dan 1,3; Gu, Yu-Cheng 2; Li, Jia1,3,4 ; Zhu, Wei-Liang1,3,4 ; Guo, Yue-Wei1,3,4
刊名	MARINE DRUGS
	2018-04
卷号	16 期号:4
关键词	Sinularia polydactyla diterpenoids PTP1B inhibitory activity
ISSN号	1660-3397
DOI	10.3390/md16040103
文献子类	Article
英文摘要	A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (4-7 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.
资助项目	Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SKLDR/SIMM Project[SIMM1705ZZ-01] ; Syngenta-SIMM-PhD Studentship Project[00000000]
WOS关键词	SARCOPHYTON-TROCHELIOPHORUM MARENZELLER ; CIRCULAR-DICHROISM SPECTRA ; MARINE TERPENES ; LOBOPHYTUM
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000431068000005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279823]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物发现与设计中心天然药物化学研究室
通讯作者	Guo, Yue-Wei
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Lead Cpds, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Ye, Fei,Zhu, Zheng-Dan,Gu, Yu-Cheng,et al. Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla[J]. MARINE DRUGS,2018,16(4).
APA	Ye, Fei,Zhu, Zheng-Dan,Gu, Yu-Cheng,Li, Jia,Zhu, Wei-Liang,&Guo, Yue-Wei.(2018).Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla.MARINE DRUGS,16(4).
MLA	Ye, Fei,et al."Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla".MARINE DRUGS 16.4(2018).