Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes

doi:10.1021/acs.orglett.8b00103

	Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes
	Fang, Feifei 1,2,3,4; Zhang, Chunmei 1,2; Zhou, Chaofan 1,2; Li, Yazhou 1,2; Zhou, Yu1,2 ; Liu, Hong1,2,3,4
刊名	ORGANIC LETTERS
	2018-04-06
卷号	20 期号:7 页码:1720-1724
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b00103
文献子类	Article
英文摘要	Rh (III)-catalyzed C-H activation of benzoylacetonitriles in coupling with diazo compounds was developed to synthesize diversified substituted benzo[de]chromenes via a formal (4 + 2) cycloaddition with a diazo compound and subsequent tandem (4 + 2) cycloaddition with another diazo compound. Intriguingly, synthesis of substituted benzo[de]chromenes and their decarboxylation products could be realized by controlling the reaction conditions. These reactions have a broad range of substrates, moderate to good yields, and high regioselectivity.
资助项目	National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Chinese Academy of Sciences[XDA12020324]
WOS关键词	PROPARGYL ALCOHOLS ; COMPOUNDS ACCESS ; BOND ACTIVATION ; CARBENOID FUNCTIONALIZATION ; CARBONYL-COMPOUNDS ; SALVIA-PRIONITIS ; INTERNAL ALKYNES ; MANSONONE-F ; ANNULATION ; INDOLES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000429886900007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279810]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Zhou, Yu; Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China; 3.China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; 4.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Fang, Feifei,Zhang, Chunmei,Zhou, Chaofan,et al. Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes[J]. ORGANIC LETTERS,2018,20(7):1720-1724.
APA	Fang, Feifei,Zhang, Chunmei,Zhou, Chaofan,Li, Yazhou,Zhou, Yu,&Liu, Hong.(2018).Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes.ORGANIC LETTERS,20(7),1720-1724.
MLA	Fang, Feifei,et al."Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes".ORGANIC LETTERS 20.7(2018):1720-1724.