Vitamin C promotes oligodendrocytes generation and remyelination

doi:10.1002/glia.23306

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	Vitamin C promotes oligodendrocytes generation and remyelination
	Guo, Yu-e 3,4; Suo, Na 3,4; Cui, Xue 2; Yuan, Qianting 4; Xie, Xin1,2,4
刊名	GLIA
	2018-07
卷号	66 期号:7 页码:1302-1316
关键词	differentiation myelin oligodendrocyte oligodendrocyte progenitor cell remyelination vitamin C
ISSN号	0894-1491
DOI	10.1002/glia.23306
文献子类	Article
英文摘要	Oligodendrocyte-formed myelin sheaths play important roles in the neuronal functions in the central nervous system. In demyelinating diseases, such as Multiple Sclerosis, the myelin sheaths are damaged and the remyelinating process is somehow hindered. Restoration of the myelin sheaths requires the differentiation of the oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs). To discover small molecule compounds that might promote the OPC to OL differentiation, a high-throughput screening system is established and L-ascorbyl-2-phosphate (As-2P), a stable form of Vitamin C (Vc), is found to greatly enhance the OPC to OL differentiation. As-2P promotes gradual expression of OL lineage markers, including O4, CNPase and MBP, in a dose- and time-dependent manner. It also facilitates the formation of myelin sheaths in OPC-neuron co-culture. As-2P also promotes the repair of the myelin sheaths in vivo and provides significant therapeutic effect in a cuprizone-mediated demyelination animal model. Interestingly, As-2P's function in promoting OPC differentiation is not related to its antioxidant activity. And an intracellular rather than an extracellular mechanism might be involved. Considering the safe use of Vc as a dietary supplement for many years, it might also be used as an alternative medicine for CNS demyelinating diseases.
资助项目	Ministry of Science and Technology of China[2015CB964503] ; Ministry of Science and Technology of China[2017YFA0104002] ; Chinese Academy of Sciences[XDA16010202] ; National Natural Science Foundation of China[81425024] ; National Natural Science Foundation of China[81472862] ; National Natural Science Foundation of China[31501189]
WOS关键词	EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; SCHWANN-CELLS INVITRO ; KAPPA-OPIOID RECEPTOR ; MULTIPLE-SCLEROSIS ; THERAPEUTIC TARGET ; PROGENITOR CELLS ; MYELIN FORMATION ; WHITE-MATTER ; BASAL LAMINA
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	WILEY
WOS记录号	WOS:000433573200002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279692]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xie, Xin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai 200092, Peoples R China; 3.Univ Chinese Acad Sci, Grad Sch, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Guo, Yu-e,Suo, Na,Cui, Xue,et al. Vitamin C promotes oligodendrocytes generation and remyelination[J]. GLIA,2018,66(7):1302-1316.
APA	Guo, Yu-e,Suo, Na,Cui, Xue,Yuan, Qianting,&Xie, Xin.(2018).Vitamin C promotes oligodendrocytes generation and remyelination.GLIA,66(7),1302-1316.
MLA	Guo, Yu-e,et al."Vitamin C promotes oligodendrocytes generation and remyelination".GLIA 66.7(2018):1302-1316.