Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica

doi:10.1016/j.phytochem.2018.04.018

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	Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica
	Xu, Ya-Ming 2; Wijeratne, E. M. Kithsiri 2; Brooks, Alan D.1,3; Tewary, Poonam 1,3; Xuan, Li-Jiang4 ; Wang, Wen-Qiong 4; Sayers, Thomas J.1,3; Gunatilaka, A. A. Leslie 2
刊名	PHYTOCHEMISTRY
	2018-08
卷号	152 页码:174-181
关键词	Physalis philadelphica Solanaceae Aeroponic cultivation Chemical investigation Withanolides Cytotoxic activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2018.04.018
文献子类	Article
英文摘要	Eleven withanolides including six previously undescribed compounds, 16 beta-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells. (C) 2018 Elsevier Ltd All rights reserved.
资助项目	Arizona Biomedical Research Commission[ADHS-16-162515] ; gs2:National Cancer Institute, National Institutes of Health[HHSN26120080001E] ; Intramural Research Program of NIH, Frederick National Lab, Center for Cancer Research[00000000]
WOS关键词	PROSTATE-CANCER ; SELECTIVE CYTOTOXICITY ; QUINONE REDUCTASE ; ERGOSTANE-TYPE ; STEROIDS ; SOLANACEAE ; INDUCTION ; PERUVIANA ; POTENT ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000437383300020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279650]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Gunatilaka, A. A. Leslie
作者单位	1.Natl Canc Inst Frederick, Canc & Inflammat Program, Frederick, MD 21702 USA; 2.Univ Arizona, Coll Agr & Life Sci, Sch Nat Resources & Environm, Nat Prod Ctr, 250 E Valencia Rd, Tucson, AZ 85706 USA; 3.Natl Canc Inst Frederick, Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Basic Res Program, Frederick, MD 21702 USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ya-Ming,Wijeratne, E. M. Kithsiri,Brooks, Alan D.,et al. Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica[J]. PHYTOCHEMISTRY,2018,152:174-181.
APA	Xu, Ya-Ming.,Wijeratne, E. M. Kithsiri.,Brooks, Alan D..,Tewary, Poonam.,Xuan, Li-Jiang.,...&Gunatilaka, A. A. Leslie.(2018).Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.PHYTOCHEMISTRY,152,174-181.
MLA	Xu, Ya-Ming,et al."Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica".PHYTOCHEMISTRY 152(2018):174-181.