Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.

doi:10.1016/j.steroids.2018.05.009

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.
	Li, Song-Wei 1,2; Chen, Wen-Ting 2; Yao, Li-Gong 2; Guo, Yue-Wei2
刊名	STEROIDS
	2018-08
卷号	136 页码:17-21
关键词	Sinularia Polyhydroxylated steroids Modified Mosher's method Cytotoxicity
ISSN号	0039-128X
DOI	10.1016/j.steroids.2018.05.009
文献子类	Article
英文摘要	Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC50 values of 1.79, 4.03 and 0.69 mu M, respectively.
资助项目	Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Natural Science Foundation of China[81603022] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SCTSM[15431901000] ; SKLDR/SIMM[SIMM 1705ZZ-01]
WOS关键词	POLYOXYGENATED STEROIDS ; PHARMACOLOGICAL-ACTIVITIES ; POLYHYDROXYLATED STEROIDS
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000438323700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279648]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Guo, Yue-Wei
作者单位	1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Song-Wei,Chen, Wen-Ting,Yao, Li-Gong,et al. Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.[J]. STEROIDS,2018,136:17-21.
APA	Li, Song-Wei,Chen, Wen-Ting,Yao, Li-Gong,&Guo, Yue-Wei.(2018).Two new cytotoxic steroids from the Chinese soft coral Sinularia sp..STEROIDS,136,17-21.
MLA	Li, Song-Wei,et al."Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.".STEROIDS 136(2018):17-21.