Synthesis and biological activity of novel shikonin analogues

doi:10.1016/j.bmcl.2008.12.032

	Synthesis and biological activity of novel shikonin analogues
	Wang, Wenjing 2; Dai, Mei 1; Zhu, Caihua 1; Zhang, Jiangang 2; Lin, Liping 1; Ding, Jian1 ; Duan, Wenhu2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2009-02-01
卷号	19 期号:3 页码:735-737
关键词	Shikonin analogue Synthesis Cytotoxicity Hypoxia-inducible factor 1 alpha
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2008.12.032
文献子类	Article
英文摘要	A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1 alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy. (C) 2008 Elsevier Ltd. All rights reserved.
资助项目	National Science Foundation of China[0801031005] ; National Science Foundation of China[0801281005] ; Chinese National Programs for High Technology Research and Development[0604071005] ; Chinese National Programs for High Technology Research and Development[0704051005]
WOS关键词	METHOXY-N-METHYLAMIDES ; NAPHTHOQUINONE DERIVATIVES ; TOPOISOMERASE-I ; INHIBITION ; CHEMISTRY ; ALKANNIN
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000262707000034
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279325]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Ding, Jian
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wenjing,Dai, Mei,Zhu, Caihua,et al. Synthesis and biological activity of novel shikonin analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(3):735-737.
APA	Wang, Wenjing.,Dai, Mei.,Zhu, Caihua.,Zhang, Jiangang.,Lin, Liping.,...&Duan, Wenhu.(2009).Synthesis and biological activity of novel shikonin analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(3),735-737.
MLA	Wang, Wenjing,et al."Synthesis and biological activity of novel shikonin analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.3(2009):735-737.