Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment

doi:10.1038/aps.2009.82

	Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment
	Wang, Juan; Zhang, Hai-yan; Tang, Xi-can
刊名	ACTA PHARMACOLOGICA SINICA
	2009-07
卷号	30 期号:7 页码:879-888
关键词	vascular dementia cholinergic deficit acetylcholinesterase inhibitor inflammation
ISSN号	1671-4083
DOI	10.1038/aps.2009.82
文献子类	Review
英文摘要	Vascular dementia (VaD) is a progressive neurodegenerative disease with a high prevalence. Several studies have recently reported that VaD patients present cholinergic deficits in the brain and cerebrospinal fluid (CSF) that may be closely related to the pathophysiology of cognitive impairment. Moreover, cholinergic therapies have shown promising effects on cognitive improvement in VaD patients. The precise mechanisms of these cholinergic agents are currently not fully understood; however, accumulating evidence indicates that these drugs may act through the cholinergic anti-inflammatory pathway, in which the efferent vagus nerve signals suppress pro-inflammatory cytokine release and inhibit inflammation, although regulation of oxidative stress and energy metabolism, alleviation of apoptosis may also be involved. In this paper, we provide a brief overview of the cholinergic treatment strategy for VaD and its relevant mechanisms of anti-inflammation.
资助项目	Ministry of Science and Technology of China[2004CB518907] ; National Natural Science Foundation of China[30801402] ; Knowledge Innovation Program of the Chinese Academy of Sciences[SIMM0709QN-2]
WOS关键词	NICOTINIC ACETYLCHOLINE-RECEPTORS ; SPONTANEOUSLY HYPERTENSIVE-RATS ; CHRONIC CEREBRAL HYPOPERFUSION ; ATTENUATES COGNITIVE DEFICITS ; L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE ; ALZHEIMERS-DISEASE PATIENTS ; OXYGEN-GLUCOSE DEPRIVATION ; TRANSIENT GLOBAL-ISCHEMIA ; HUPERZINE-A ; DOUBLE-BLIND
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:3628661
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000268066400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279188]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tang, Xi-can
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Juan,Zhang, Hai-yan,Tang, Xi-can. Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment[J]. ACTA PHARMACOLOGICA SINICA,2009,30(7):879-888.
APA	Wang, Juan,Zhang, Hai-yan,&Tang, Xi-can.(2009).Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.ACTA PHARMACOLOGICA SINICA,30(7),879-888.
MLA	Wang, Juan,et al."Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment".ACTA PHARMACOLOGICA SINICA 30.7(2009):879-888.