Alkaloids from the Leaves of Daphniphyllum subverticillatum | |
Zhang, Chuan-Rui; Liu, Hong-Bing; Feng, Teng; Zhu, Jian-Yong; Geng, Mei-Yu; Yue, Jian-Min | |
刊名 | JOURNAL OF NATURAL PRODUCTS |
2009-09 | |
卷号 | 72期号:9页码:1669-1672 |
ISSN号 | 0163-3864 |
DOI | 10.1021/np9003799 |
文献子类 | Article |
英文摘要 | Four new alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC50 values in the range 2.4-9.7 mu M and against the HMEC human microvascular endothelial cell line with an IC50 of 2.7 mu M. |
资助项目 | National Natural Science Foundation[30630072] ; National Natural Science Foundation[30721005] |
WOS关键词 | GRACILE GAUGE ; LONGERACEMOSUM ; HUMILE ; CODAPHNIPHYLLINE ; DAPHNEZOMINES ; CALYCINUM ; PAXIANUM ; SKELETON ; ASSAY |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000270855600021 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279150] |
专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Yue, Jian-Min |
作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Chuan-Rui,Liu, Hong-Bing,Feng, Teng,et al. Alkaloids from the Leaves of Daphniphyllum subverticillatum[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(9):1669-1672. |
APA | Zhang, Chuan-Rui,Liu, Hong-Bing,Feng, Teng,Zhu, Jian-Yong,Geng, Mei-Yu,&Yue, Jian-Min.(2009).Alkaloids from the Leaves of Daphniphyllum subverticillatum.JOURNAL OF NATURAL PRODUCTS,72(9),1669-1672. |
MLA | Zhang, Chuan-Rui,et al."Alkaloids from the Leaves of Daphniphyllum subverticillatum".JOURNAL OF NATURAL PRODUCTS 72.9(2009):1669-1672. |
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