Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

doi:10.1126/science.1176709

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	Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
	Hait, Nitai C.2,3; Allegood, Jeremy 2,3; Maceyka, Michael 2,3; Strub, Graham M.2,3; Harikumar, Kuzhuvelil B.2,3; Singh, Sandeep K.2,3; Luo, Cheng4,5,6 ; Marmorstein, Ronen 4,5; Kordula, Tomasz 2,3; Milstien, Sheldon 1
刊名	SCIENCE
	2009-09-04
卷号	325 期号:5945 页码:1254-1257
ISSN号	0036-8075
DOI	10.1126/science.1176709
文献子类	Article
英文摘要	The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with histone H3 and produced S1P that regulated histone acetylation. S1P specifically bound to the histone deacetylases HDAC1 and HDAC2 and inhibited their enzymatic activity, preventing the removal of acetyl groups from lysine residues within histone tails. SphK2 associated with HDAC1 and HDAC2 in repressor complexes and was selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. Thus, HDACs are direct intracellular targets of S1P and link nuclear S1P to epigenetic regulation of gene expression.
资助项目	NIH[R37GM043880] ; NIH[R01CA61774] ; National Research Service Award[F30NSO58008] ; NIMH Intramural Research Program[00000000]
WOS关键词	MEDIATED PHOSPHORYLATION ; DEACETYLASE INHIBITORS ; SPHINGOSINE-KINASE-2 ; ACTIVATION ; FAMILY
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000269523200040
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279136]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Spiegel, Sarah
作者单位	1.NIMH, NIH, Bethesda, MD 20892 USA 2.Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA; 3.Virginia Commonwealth Univ, Sch Med, Massey Canc Ctr, Richmond, VA 23298 USA; 4.Univ Penn, Dept Chem, Philadelphia, PA 19104 USA; 5.Univ Penn, Wistar Inst, Philadelphia, PA 19104 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Hait, Nitai C.,Allegood, Jeremy,Maceyka, Michael,et al. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate[J]. SCIENCE,2009,325(5945):1254-1257.
APA	Hait, Nitai C..,Allegood, Jeremy.,Maceyka, Michael.,Strub, Graham M..,Harikumar, Kuzhuvelil B..,...&Spiegel, Sarah.(2009).Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate.SCIENCE,325(5945),1254-1257.
MLA	Hait, Nitai C.,et al."Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate".SCIENCE 325.5945(2009):1254-1257.