Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa

doi:10.1021/np900484k

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	Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa
	Li, Yan 2; Carbone, Marianna 1; Vitale, Rosa Maria 1; Amodeo, Pietro 1; Castelluccio, Francesco 1; Sicilia, Giovanna 1; Mollo, Ernesto 1; Nappo, Michela 1; Cimino, Guido 1; Guo, Yue-Wei2
刊名	JOURNAL OF NATURAL PRODUCTS
	2010-02
卷号	73 期号:2 页码:133-138
ISSN号	0163-3864
DOI	10.1021/np900484k
文献子类	Article
英文摘要	A series of nine casbane diterpenes, compounds 5-13. exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa. The structures of this group of compounds, the basic member of which was named depressin (5), were established by detailed spectroscopic analysis. In addition, the absolute configuration of the main metabolite, 10-hydroxydepressin (7), and of its epimer, 1-epi-10-hydroxydepressin (8). was determined by it combination of conformational analysis and the modified Mosher's method. A stereochemical relationship between all isolated molecules was investigated by analyzing then circular dichroism profiles. Antiproliferative and antibacterial activities of the depressins were also evaluated.
资助项目	national S & T major project[20092X09301-001] ; national marine 863 project[2007AA09Z447] ; NSFC[40976048] ; NSFC[30730108] ; NSFC[20721003] ; CAS[KSX2-YW-R-18] ; CAS[SIMM0907KF-09] ; PRIN-MIUR[00000000]
WOS关键词	SARCOPHYTON-LATUM ; FORCE-FIELD ; IDENTIFICATION ; TERPENOIDS ; CHEMISTRY ; MODEL
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000274803600008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278984]
专题	天然药物化学研究室中科院受体结构与功能重点实验室信息中心新药研究国家重点实验室药理学第一研究室
通讯作者	Guo, Yue-Wei
作者单位	1.CNR, ICB, I-80078 Naples, Italy 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Li, Yan,Carbone, Marianna,Vitale, Rosa Maria,et al. Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):133-138.
APA	Li, Yan.,Carbone, Marianna.,Vitale, Rosa Maria.,Amodeo, Pietro.,Castelluccio, Francesco.,...&Gavagnin, Margherita.(2010).Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa.JOURNAL OF NATURAL PRODUCTS,73(2),133-138.
MLA	Li, Yan,et al."Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa".JOURNAL OF NATURAL PRODUCTS 73.2(2010):133-138.