AMPK Activators as Novel Therapeutics for Type 2 Diabetes

doi:10.2174/156802610790980611

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	AMPK Activators as Novel Therapeutics for Type 2 Diabetes
	Yu, Li-Fang; Qiu, Bei-Ying; Nan, Fa-Jun; Li, Jia
刊名	CURRENT TOPICS IN MEDICINAL CHEMISTRY
	2010-03
卷号	10 期号:4 页码:397-410
ISSN号	1568-0266
DOI	10.2174/156802610790980611
文献子类	Review
英文摘要	AMPK is a potential target of metabolic diseases including obesity and type 2 diabetes. The activation of AMPK can lead to an increase of glucose uptake into muscle, decreased gluconeogenesis in liver, increased fatty acid oxidation in muscle and liver, decreased fatty acid synthesis in liver and adipose tissue, and increase mitochondrial biogenesis. Until now, many efforts from industrial and academia have been focused on searching novel agents that activate AMPK directly or indirectly. This review will discuss recent advances in the search for novel therapeutic agents that mediate their activity via AMPK activation.
资助项目	National Natural Science Foundation of China[30623008]
WOS关键词	5'-AMP-ACTIVATED PROTEIN-KINASE ; IMPROVES GLUCOSE-METABOLISM ; RESPIRATORY COMPLEX-I ; INSULIN ACTION ; GREEN TEA ; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE ; INDEPENDENT MECHANISM ; CELLULAR-ENERGY ; SKELETAL-MUSCLE ; GENE-EXPRESSION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000275929700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278962]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Nan, Fa-Jun
作者单位	Chinese Acad Sci, Chinese Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yu, Li-Fang,Qiu, Bei-Ying,Nan, Fa-Jun,et al. AMPK Activators as Novel Therapeutics for Type 2 Diabetes[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2010,10(4):397-410.
APA	Yu, Li-Fang,Qiu, Bei-Ying,Nan, Fa-Jun,&Li, Jia.(2010).AMPK Activators as Novel Therapeutics for Type 2 Diabetes.CURRENT TOPICS IN MEDICINAL CHEMISTRY,10(4),397-410.
MLA	Yu, Li-Fang,et al."AMPK Activators as Novel Therapeutics for Type 2 Diabetes".CURRENT TOPICS IN MEDICINAL CHEMISTRY 10.4(2010):397-410.