Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine receptors

	Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine receptors
	Chen, LJ; Zhou, QT; Dong, ZJ; Yu, LP; Jin, GZ
刊名	ACTA PHARMACOLOGICA SINICA
	1999-10
卷号	20 期号:10 页码:884-888
关键词	12-chloroscoulerine l-stepholidine apomorphine dopamine D-1 receptors Sch23390 radioligand assay stereotyping catalepsy locomotion
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To compare the pharmacological characteristics of 12-chloroscoulerine (CSL) enantiomers to dopamine (DA) receptors. METHODS: Radioligand receptor binding assay with calf striatum and behavioral tests of mice or rats were used. RESULTS: In the competitive binding assay, the affinities (K-i) of l-CSL to D-1 and D-2 receptors were 5.1 nmol.L-1, while those of d-CSL for D-1 and D-2 receptors were 135 and 9150 nmol.L-1, respectively. The K-i of dl-CSL to D-1 and D-2 receptors were 8.9 and 9.6 nmol.L-1, respectively, which were slightly weaker than that of l-CSL. In the behavioral experiments, CSL enantiomers 5 - 60 mg.kg(-1) antagonized the stereotypy induced by apomorphine in rats, and 5 - 150 mg.kg(-1) produced catalepsy. The enantiomers 10 - 60 mg.kg(-1) reduced the mice jumping behavior induced by amphetamine + levodopa. l-CSL 10 - 80 mg.kg(-1) antagonized the spontaneous locomotor activity of normal or amphetamine-treated mice. CONCLUSION: CSL enantiomers are antagonists to DA receptors: l-CSL > dl-CSL > > d-CSL.
WOS关键词	BRAIN ; TETRAHYDROPROTOBERBERINES ; TETRAHYDROPALMATINE ; (-)-STEPHOLIDINE ; RATS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000083036100004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274684]
专题	院士及顾问专家成果转移转化处
通讯作者	Jin, GZ
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Chen, LJ,Zhou, QT,Dong, ZJ,et al. Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine receptors[J]. ACTA PHARMACOLOGICA SINICA,1999,20(10):884-888.
APA	Chen, LJ,Zhou, QT,Dong, ZJ,Yu, LP,&Jin, GZ.(1999).Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine receptors.ACTA PHARMACOLOGICA SINICA,20(10),884-888.
MLA	Chen, LJ,et al."Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine receptors".ACTA PHARMACOLOGICA SINICA 20.10(1999):884-888.