Complicated intermolecular interactions formed between organofluorine and drug target

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物发现与设计中心

	Complicated intermolecular interactions formed between organofluorine and drug target
	WANG Gui-min 1,2; ZHU Zheng-dan 1,2; CHEN Zhao-qiang 2; XU Zhi-jian2 ; ZHU Wei-liang1,2
刊名	Acta Pharmaceutica Sinica
	2018
卷号	53 期号:5 页码:701-708
关键词	organofluorine weak intermolecular interaction hydrogen bond halogen bond C-F⋯pi interaction
ISSN号	0513-4870
其他题名	有机含氟药物与靶标蛋白质的复杂分子间相互作用
文献子类	Review
英文摘要	Fluorinated compounds, which now make up 20%-25% of all marketed chemical drugs, are playing significant role and showing great potential in medicinal chemistry. Fluorine substitution is always utilized to change the physicochemical properties of the compounds to improve the ADME/T properties. In addition, fluorine substitution leads to improvement of the ligand binding affinity. With respect to molecular level, organofluorine can form various intermolecular interactions with the target proteins, e.g., hydrogen bond, halogen bond, C-F⋯pi interaction, polar interaction and so on. These interactions display unique properties or nature due to the specificity of fluorine atom, which are at the center of attention. This paper reviews the related research background, followed by the research progress of hydrogen bond, halogen bond, C-F⋯pi interaction, polar interaction and some other interactions involved organofluorine.
资助项目	国家重点研发计划资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6248861
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269172]
专题	药物发现与设计中心
通讯作者	ZHU Wei-liang
作者单位	1.University of Chinese Academy of Sciences, Beo＇ing 100049, China 2.CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
推荐引用方式 GB/T 7714	WANG Gui-min,ZHU Zheng-dan,CHEN Zhao-qiang,et al. Complicated intermolecular interactions formed between organofluorine and drug target[J]. Acta Pharmaceutica Sinica,2018,53(5):701-708.
APA	WANG Gui-min,ZHU Zheng-dan,CHEN Zhao-qiang,XU Zhi-jian,&ZHU Wei-liang.(2018).Complicated intermolecular interactions formed between organofluorine and drug target.Acta Pharmaceutica Sinica,53(5),701-708.
MLA	WANG Gui-min,et al."Complicated intermolecular interactions formed between organofluorine and drug target".Acta Pharmaceutica Sinica 53.5(2018):701-708.