Progress in the studies of the structure and function of mitochondria permeability transition pore

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	Progress in the studies of the structure and function of mitochondria permeability transition pore
	Guo Hongxia; Tu Changying; Chen Jing; Jiang Hualiang; Shen Xu
刊名	Chinese Bulletin of Life Sciences
	2005
卷号	17 期号:1 页码:49-54
关键词	MPTP (mitochondria permeability transition pore) ANT (adenine nucleotide translocator) CypD (cyclophilin D) VDAC (voltage-dependent anion channel) CSA (Cyclosporin A)
ISSN号	1004-0374
其他题名	线粒体渗透性转变孔结构和功能的研究进展
文献子类	Article
英文摘要	Abnormally high concentration of Ca2+ and oxide stress can stimulate the opening of the mitochondria permeability transition pore (MPTP) and cause the change of mitochondria shape and function. The factors released by mitochondria, such as cytochrome c and AIF (apoptosis-inducing factor) involve in the signaling pathway of caspases and induce cell apoptosis. This article describes the recent progress in the studies of the main components and two different models of the MPTP, the mechanism of the inhibition of CSA and Sf A to MPTP and the influence of ischemia /reperfusion and ischaemic preconditioning to the opening of MPTP.
资助项目	国家自然科学基金项目[00000000] ; 国家"973"项目[00000000]
WOS研究方向	Cell Biology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:1874979
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268338]
专题	药物安全性评价中心药物发现与设计中心
作者单位	Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Guo Hongxia,Tu Changying,Chen Jing,et al. Progress in the studies of the structure and function of mitochondria permeability transition pore[J]. Chinese Bulletin of Life Sciences,2005,17(1):49-54.
APA	Guo Hongxia,Tu Changying,Chen Jing,Jiang Hualiang,&Shen Xu.(2005).Progress in the studies of the structure and function of mitochondria permeability transition pore.Chinese Bulletin of Life Sciences,17(1),49-54.
MLA	Guo Hongxia,et al."Progress in the studies of the structure and function of mitochondria permeability transition pore".Chinese Bulletin of Life Sciences 17.1(2005):49-54.