One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone

doi:10.1021/ol101644g

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	One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone
	Li, Qingjiang 1; Fan, Aili 1; Lu, Zhiyao 1; Cui, Yuxin 1; Lin, Wenhan 1; Jia, Yanxing 1,2
刊名	ORGANIC LETTERS
	2010-09-17
卷号	12 期号:18 页码:4066-4069
ISSN号	1523-7060
DOI	10.1021/ol101644g
文献子类	Article
英文摘要	A simple and efficient method for the synthesis of 1,3,4-trisubstituted or 3,4-disubstituted pyrroles has been developed. The reaction represents the first time that pyrroles are synthesized directly from readily available aldehydes and amines (anilines) as starting materials. This method has been successfully applied to the rapid synthesis of purpurone.
资助项目	National Basic Research Program of China (973 Program)[2010CB833200] ; State Key Laboratory of Drug Research[00000000] ; National Natural Science Foundation of China[20972007] ; National Natural Science Foundation of China[20802005] ; National Natural Science Foundation of China[30930109] ; NCET[00000000]
WOS关键词	EFFICIENT TOTAL-SYNTHESIS ; C BOND FORMATION ; N-ARYL ENAMINES ; LEAD-TETRAACETATE ; SUBSTITUTED PYRROLES ; SEQUENTIAL REACTIONS ; COUPLING REACTIONS ; DIRECT ANNULATION ; ALPHA-ARYLATION ; OXIDATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000281596800027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278773]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Jia, Yanxing
作者单位	1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Qingjiang,Fan, Aili,Lu, Zhiyao,et al. One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone[J]. ORGANIC LETTERS,2010,12(18):4066-4069.
APA	Li, Qingjiang,Fan, Aili,Lu, Zhiyao,Cui, Yuxin,Lin, Wenhan,&Jia, Yanxing.(2010).One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone.ORGANIC LETTERS,12(18),4066-4069.
MLA	Li, Qingjiang,et al."One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone".ORGANIC LETTERS 12.18(2010):4066-4069.